IL23A Protein (AA 20-189) (His tag)

N° du produit ABIN7504447

Détail du produit

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Type de proteíne: Recombinant

Attributs du protein: AA 20-189

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL23A protéine est marqué à la His tag.

Fonction: Human IL-23 alpha & IL-12 beta Protein

Séquence: Arg20-Pro189 (IL-23 alpha) & Ile23-Ser328 (IL-12 beta)

Specificité: Uni-Prot: Q9NPF7 (IL-23 alpha), P29460 (IL-12 beta)

Attributs du produit: Recombinant Human IL-23 alpha & IL-12 beta Protein is expressed from HEK293 with His tag at the C-terminus.It contains Arg20-Pro189(IL-23 alpha) & Ile23-Ser328(IL-12 beta).

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Autre désignation: IL-23 alpha (IL23A Produits)

Synonymes: IL-23 Protein, IL-23A Protein, IL23P19 Protein, P19 Protein, SGRF Protein, FIL1 Protein, FIL1(ZETA) Protein, FIL1Z Protein, IL-1F7 Protein, IL-1H Protein, IL-1H4 Protein, IL-1RP1 Protein, IL-37 Protein, IL1F7 Protein, IL1H4 Protein, IL1RP1 Protein, p19 Protein, il23p19 Protein, IL23 Protein, interleukin 23 subunit alpha Protein, interleukin 37 Protein, interleukin 23, alpha subunit p19 Protein, IL23A Protein, IL37 Protein, Il23a Protein

Sujet: The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.

Poids moléculaire: 19.77 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Due to glycosylation, the protein migrates to 23 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Tris-Bis PAGE result.

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation