APOH Protein (His tag)

N° du produit ABIN7535692

Détail du produit

Antigène: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette APOH protéine est marqué à la His tag.

Fonction: Recombinant Human Apolipoprotein H/ApoH Protein

Séquence: GRTCPKPDDL PFSTVVPLKT FYEPGEEITY SCKPGYVSRG GMRKFICPLT GLWPINTLKC TPRVCPFAGI LENGAVRYTT FEYPNTISFS CNTGFYLNGA DSAKCTEEGK WSPELPVCAP IICPPPSIPT FATLRVYKPS AGNNSLYRDT AVFECLPQHA MFGNDTITCT THGNWTKLPE CREVKCPFPS RPDNGFVNYP AKPTLYYKDK ATFGCHDGYS LDGPEEIECT KLGNWSAMPS CKASCKVPVK KATVVYQGER VKIQEKFKNG MLHGDKVSFF CKNKEKKCSY TEDAQCIDGT IEVPKCFKEH SSLAFWKTDA SDVKPC

Specificité: Gly20-Cys345

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.1EU/μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Autre désignation: Apolipoprotein H/ApoH (APOH Produits)

Synonymes: B2G1 Protein, B2GP1 Protein, BG Protein, BETA2 Protein, BHF-1 Protein, MODY6 Protein, NEUROD Protein, bHLHa3 Protein, apoh Protein, APOH Protein, B2GPI Protein, beta-2-GPI Protein, beta2-GPI Protein, LOC100227913 Protein, apolipoprotein H Protein, neuronal differentiation 1 Protein, APOH Protein, NEUROD1 Protein, apoh Protein, Apoh Protein

Sujet:

Description: Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. It is an essential cofactor for the binding of certain antiphospholipid antibodies (APA) to anionic phospholipid. APOH binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. APOH may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. APOH appears to completely inhibit serotonin release by the platelets and prevents subsequent waves of the ADP-induced aggregation. The activity of APOH appears to involve the binding of agglutenating, negatively charged compounds, and inhibits agglutenation by the contact activation of the intrinsic blood coagulation pathway.

Name: APOH,B2G1,B2GP1,BG

ID gène: 350

UniProt: P02749