MOG Protein (His tag)

N° du produit ABIN7535297

Détail du produit

Antigène: MOG (Myelin Oligodendrocyte Glycoprotein (MOG))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette MOG protéine est marqué à la His tag.

Fonction: Active Recombinant Human Myelin-oligodendrocyte glycoprotein/MOG Protein

Séquence: GQFRVIGPRH PIRALVGDEV ELPCRISPGK NATGMEVGWY RPPFSRVVHL YRNGKDQDGD QAPEYRGRTE LLKDAIGEGK VTLRIRNVRF SDEGGFTCFF RDHSYQEEAA MELKVEDPFY WVSPG

Specificité: Gly30-Gly154

Pureté: > 95 % by SDS-PAGE.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: <0.1EU/μg

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized Human MOG at 1 μg/mL (100 μL/well) can bind Myelin oligodendrocyte glycoprotein Rabbit mAb with a linear range of 0.98-2.5 ng/mL

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C,-80 °C

Stockage commentaire: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Détail du antigène

Antigène: MOG (Myelin Oligodendrocyte Glycoprotein (MOG))

Autre désignation: Myelin-oligodendrocyte glycoprotein/MOG (MOG Produits)

Synonymes: MOGIG2 Protein, NRCLP7 Protein, B230317G11Rik Protein, MOG Protein, myelin oligodendrocyte glycoprotein Protein, MOG Protein, Mog Protein

Sujet:

Description: Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1 % total proteins) in the oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce demyelinating multiple sclerosis-like diseases in experimental animals.

Name: BTN6, BTNL11, MOGIG2, NRCLP7,MOG,BTNL11,MOGIG2,NRCLP7

ID gène: 4340

UniProt: Q16653