IL-6 Protéine
Aperçu rapide pour IL-6 Protéine (ABIN7539339)
Antigène
Voir toutes IL-6 (IL6) ProtéinesType de proteíne
Activité biologique
Origine
Source
Pureté
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Fonction
- IL-6
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Séquence
- MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
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Specificité
- Chromosomal location:5 B1, 5 17.0 cM
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Réactivité croisée
- Singe, Souris, Rat, Truite
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Attributs du produit
- Length (aa):188
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niveau d'endotoxine
- < 0.1 ng/μg of protein (<1EU/μg)
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Interleukin 6 (IL6) (AA 30-212) protein (mFc-His Tag)
IL6 Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
Interleukin 6 (IL6) (AA 30-212) proteinIL6 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 6 (IL6) (AA 28-212) protein (His tag)IL6 Origine: Cynomolgus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 (IL6) (AA 29-212) (Active) proteinIL6 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Interleukin 6 (IL6) (AA 25-211) (Active) protein (His tag)IL6 Origine: Souris Hôte: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Origine: Humain Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)IL6 Origine: Humain Hôte: HEK-293 Cells > 97 % AcA, CC Active
Interleukin 6 (IL6) (AA 47-241) protein (His tag)IL6 Origine: Poulet Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 6 (IL6) (AA 21-207) protein (His tag)IL6 Origine: Chien Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Indications d'application
- The ED50 as determined by the dose-dependent stimulation of murine hybridoma B9 cells is in the range of 5-20 pg/mL.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- 50 mM Acetic Acid
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Buffer
- 50 mM Acetic Acid
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- IL-6 (IL6) (Interleukin 6 (IL6))
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Autre désignation
- IL-6
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Sujet
- Il6, Il-6,IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
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Poids moléculaire
- 21.7 kDa
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ID gène
- 16193
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NCBI Accession
- NM_031168, NP_112445
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UniProt
- P08505
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Pathways
- Signalisation TLR, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
Antigène
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