ErbB2/Her2 Protéine

N° du produit ABIN7849668

Protéine Native ErbB2/Her2 exprimée dans Human.

Aperçu rapide pour ErbB2/Her2 Protéine (ABIN7849668)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Type de proteíne: Native

Origine: Humain

Source: Human

Application: SDS-PAGE (SDS)

Pureté: > 90 % by SDS-PAGE

Détail du produit

Fonction: Native Human Epidermal growth factor receptor-2, HER2 Protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mMPBS, pH 7.4.

Stock: 4 °C,-20 °C

Stockage commentaire: Ship at 4°C.Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.

Détail du antigène

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: HER2

Sujet:

Synonyms: erbB-2 isoform 2, HER2 receptor, Erbb2 protein, CerbB2, c erb B2, C erbB 2, C-erbB2, CD340, Erb B2, erbb2, HER 2, Her-2, HER 2/neu, HER2, Her2/neu, Herstatin, MLN 19, MLN19, NEU, NEU Proto Oncogene, Neuro Glioblastoma Derived Oncogene Homolog, NGL, p185 ErbB2, p185erbB2, Receptor Protein Tyrosine Kinase ErbB2 Precursor, Receptor tyrosine protein kinase erbB 2, TKR1, Tyrosine kinase type cell surface receptor HER2, v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian), Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2.

Description: Purified human epidermalgrowth factor receptor-2, HER2 protein.

Background: Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30 % of breast cancer patients.

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development