RPS6KA2 Protéine
Aperçu rapide pour RPS6KA2 Protéine (ABIN7939515)
Antigène
Voir toutes RPS6KA2 ProtéinesType de proteíne
Origine
Source
Application
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Fonction
- Recombinant RPS6KA2/RSK3 protein
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Buffer
- Recombinant RPS6KA2 / RSK3 protein is supplied at a concentration in 25 mM HEPES, NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Stock
- -80 °C
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Stockage commentaire
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))
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Autre désignation
- RPS6KA2 & RSK3
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Sujet
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Protein Background: RPS6KA2 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. RPS6KA2 acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. Diseases associated with RPS6KA2 include Coffin-Lowry Syndrome and Dyskeratosis Congenita, Autosomal Dominant 3.
Short Description: Recombinant RPS6KA2 / RSK3 protein was expressed in baculovirus expression system as the full-length protein (accession number NP_066958.2) with a N-terminal FLAG tag. The molecular weight of the protein is 84.5 kDa.
Aliases: ribosomal S6 kinase
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Pathways
- Signalisation MAPK, Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades
Antigène
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