RPS6KA2 Protein (GST tag)

N° du produit ABIN7317081

Détail du produit

Antigène: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette RPS6KA2 protéine est marqué à la GST tag.

Fonction: Recombinant Human RSK3/RPS6KA2 Protein (GST Tag)(Active)

Séquence: Met 1-Leu 733

Attributs du produit: A DNA sequence encoding the human RPS6KA2 isoform 1 (Q15349-1) (Met 1-Leu 733) was fused with the GST tag at the N-terminus.

Pureté: > 84 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 41 nmol/min/mg using synthetic RSK peptide (KRRRLSSLRA) as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.0, 20 mM GSH

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Autre désignation: RSK3/RPS6KA2 (RPS6KA2 Produits)

Synonymes: HU-2 Protein, MAPKAPK1C Protein, RSK Protein, RSK3 Protein, S6K-alpha Protein, S6K-alpha2 Protein, p90-RSK3 Protein, pp90RSK3 Protein, 90kDa Protein, D17Wsu134e Protein, Rps6ka-rs1 Protein, Rsk3 Protein, p90rsk Protein, pp90rsk Protein, ribosomal protein S6 kinase A2 Protein, ribosomal protein S6 kinase, polypeptide 2 Protein, Rps6ka2 Protein, RPS6KA2 Protein

Sujet:

Background: Ribosomal protein S6 kinase alpha-2, also known as 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 arrest, increased apoptosis, reduced levels of phosphorylated extracellular signal-regulated kinase and altered other cell cycle proteins. RPS6KA2 / RSK-3 contains one AGC-kinase C-terminal domain and two protein kinase domains. It forms a complex with either ERK1 or ERK2 in quiescent cells. It transiently dissociates following mitogenic stimulation. RPS6KA2 / RSK-3 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 are involved in several pathways central to the carcinogenic process, including regulation of cell growth, insulin, and inflammation. 

Synonym: HU-2;MAPKAPK1C;p90-RSK3;pp90RSK3;RSK;RSK3;S6K-alpha;S6K-alpha2

Poids moléculaire: 110 kDa

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades