IGFBP4 Protéine
Aperçu rapide pour IGFBP4 Protéine (ABIN935568)
Antigène
Voir toutes IGFBP4 ProtéinesType de proteíne
Activité biologique
Origine
Source
Pureté
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Séquence
- DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
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Attributs du produit
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Purified recombinant Human IGF BP4 protein
Expression System: Hi-5 cells
Bioactivity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. -
niveau d'endotoxine
- < 0.1 ng per µg (1 EU/µg).
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Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 22-258) protein (His-IF2DI Tag)
IGFBP4 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) protein (GST tag)IGFBP4 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) (Active) protein (His tag)IGFBP4 Origine: Humain Hôte: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Commentaires
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Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
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Stock
- RT/-20 °C
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- IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
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Autre désignation
- IGF BP4
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Sujet
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IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF1ndependent pathway.
Alternative Names: Insulin-like Growth Factor-Binding Protein 4 protein, IGF BP-4, IGF BP 4 protein, IBP-4 protein, IGF BP4, colon cancer cell growth inhibitor protein, IGF BP-4 protein, HT29-IGF-BP protein, IGF BP-4 protein, IGF BP 4 -
Poids moléculaire
- 25.8 kDa
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Pathways
- Signalisation WNT, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
Antigène
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