IGFBP4 Protein (His tag)

N° du produit ABIN7318629

Détail du produit

Antigène: IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette IGFBP4 protéine est marqué à la His tag.

Fonction: Recombinant Human IGFBP-4/IGFBP4 Protein (His Tag)

Séquence: Asp22-Glu258

Attributs du produit: Recombinant Human Insulin-Like Growth Factor-Binding Protein 4 is produced by our Mammalian expression system and the target gene encoding Asp22-Glu258 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))

Autre désignation: IGFBP-4/IGFBP4 (IGFBP4 Produits)

Synonymes: IGFBP4 Protein, igfbp4 Protein, BP-4 Protein, HT29-IGFBP Protein, IBP4 Protein, IGFBP-4 Protein, AI875747 Protein, Deb2 Protein, IGF-BP4 Protein, IBP-4 Protein, insulin like growth factor binding protein 4 Protein, insulin-like growth factor-binding protein 4 Protein, insulin-like growth factor binding protein 4 Protein, IGFBP4 Protein, LOC100136305 Protein, LOC100194498 Protein, igfbp4 Protein, Igfbp4 Protein

Sujet:

Background: Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24 kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. All members of the IGFBP family can bind IGF-I and IGF-II with about equal affinity, but IGFBP-4 binds IGF2 more than IGF1. It contains IGFBP N-terminal domain and thyroglobulin type-1 domain. IGFBP-4 is induced by forskolin and N6, O2'dibutyryl sdenosine 3', or 5'-cyclic monophosphate. The IGF-binding proteins can prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Synonym: Insulin-Like Growth Factor-Binding Protein 4, IBP-4, IGF-Binding Protein 4, IGFBP-4, IGFBP4, IBP4

Poids moléculaire: 27.0 kDa

UniProt: P22692

Pathways: Signalisation WNT, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process