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anti-Human RAC1 Anticorps:
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Human Polyclonal RAC1 Primary Antibody pour ELISA, WB - ABIN543938
Gorshkova, He, Berdyshev, Usatuyk, Burns, Kalari, Zhao, Pendyala, Garcia, Pyne, Brindley, Natarajan: Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. dans The Journal of biological chemistry 2008
Show all 3 Pubmed References
Human Polyclonal RAC1 Primary Antibody pour WB - ABIN3043366
Shen, Yang, Yao, Sun, Chen, Mo, Shi, Chen, Liu: Gadolinium promoted proliferation in mouse embryo fibroblast NIH3T3 cells through Rac and PI3K/Akt signaling pathways. dans Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2015
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Human Polyclonal RAC1 Primary Antibody pour IF, WB - ABIN6146615
Liu, Feng, Chen, Luo, Yan, Chen, Lin, Ding, Wen: Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition. dans Molecular neurobiology 2018
we show that HIV-1 infection of human T cells sequesters both Lck and Rac1 in a pericentrosomal compartment in an Nef-dependent manner.
High RAC1 expression is associated with liver cancer.
These findings highlight a novel mechanism for resistance to ER-stress through oncogenic activation of MEK/ERK signalling by RAC1 and NRAS.
Expression of the RAC1, RHOA, and CXCR4 proteins and their interactions play a role as risk factors for infiltration to the nipple areola complex in operable breast carcinoma.
Results show the involvement of RAC1 in the inflammatory process of FMF by enhancing IL-1beta production, through caspase-1 activation, and generating oxidative stress, even during asymptomatic periods.
this study shows that downregulated Rac1 promotes apoptosis and inhibits the clearance of apoptotic cells in airway epithelial cells
Data suggest rac1 GTP-binding protein (RAC1-GTP) directly interacte with activators of transcription 3 (STAT3) to promote STAT3 phosphorylation, thus promoted epithelial-mesenchymal transition (EMT) of colorectal cancer (CRC) cells.
NMI and RAC1 might represent two new key genes related to gastric cancer
the results indicated that Rac1 acted as the bona fide target of miR-224 and that Rac1 depletion promoted osteogenic differentiation in miR-224-silenced hMSCs.
Cessation of Rac1 activity induces a complete and rapid structural transition.
ARHGEF39 promotes tumor growth and invasion by activating the Rac1-P38-ATF2 signaling pathway, as well as increasing the expression of Cyclin A2, Cyclin D1, and MMP2 in NSCLC cells.
The findings uncovered a critical HGF-dependent signaling pathway that involves the assembly of a large protein complex consisting of MET, AXL, ELMO2, and DOCK180 on the plasma membrane, leading to RAC1-dependent cell migration and invasion in various cancer cells.
Low RAC1 expression promotes lung tumor metastasis.
An activated and novel splice variant of Rac1.
Induced association of beta-PIX with GIT1 is essential for the stimulation of intestinal epithelial restitution by activating Rac1, and this signaling pathway is tightly regulated by cellular polyamines.
upregulation of EMP1 significantly increases cancer cell migration that leads to tumor metastasis
Hypermethylation and the deletion of DMTN relieved binding to the ARHGEF2 protein, activated the Rac1 signaling pathway, regulated actin cytoskeletal rearrangements, and promoted the invasion and metastasis of CRC cells.
This novel molecular axis (CUL3/KCTD10/RhoB) positively regulates the activity of Rac1 in HER2-positive breast cancers.
RAC1/ced-10 participates in Parkinson's disease associated pathogenesis
These results demonstrate a novel physiological function for sema4D/plxnB1 signaling in retinal pigment epithelium phagocytosis.
Overall, our study unveils the prevalence of a Wnt5A-Rac1-Disheveled-mediated actin-associated autophagy circuit as an important component of innate immunity in host macrophages that may turn out crucial for restricting infection by leading bacterial pathogens.
Loss of RhoA and Cdc42 reduced alphaSMA expression, ablation of the Rac1 gene had the opposite effect.
Study shows that neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke. Results demonstrate that Rac1 plays important roles in the ischemic pathological cascade and that modulation of its levels is of therapeutic interest.
Rac1 plays a crucial role in the pathogenesis of renal fibrosis after IR via regulation of expressions of profibrotic molecules, bone-marrow derived M2 macrophages recruitment, and M2 macrophages-myofibroblasts transition.
Results show that Rac1-dependent mechanisms in hepatocytes and non-hepatocytes contribute to the maintenance of liver immune homeostasis under basal situation and following LPS-induced endotoxemia. Disturbed Rac1-regulated hepatocyte functions may promote liver damage under pathophysiological situation involving inflammatory stress.
Selective inhibition or knockdown of Rac1 decreased IL-6 and IL-8 release in 16HBE cells induced by cigarette smoke extract (CSE), which correlated with CSE-induced Rac1-regulated Erk1/2 mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription-3 (STAT3) signaling.
This study demonstrated that Rac1 plays vital roles in brain plasticity and functional recovery after experimental stroke.
Authors show that a vinculin-mediated link was not only critical for Rac1 induction and actin rearrangements, but was also important for the induction of a Rab5-dependent increase in the number of early endosomes.
Rac1 and Cdc42 have cooperating roles in regulation of bone development.
These findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis.
Rac1 role in the hippocampal inhibitory neurons.ArhGAP15 modulation of Rac1 activity in the hippocampus.
Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of G-protein-coupled receptors.
These findings suggest a causal relationship between increased Rac1-cofilin signaling, synaptic defects, and impaired sensory processing in fragile X syndrome (FXS) and uncover a previously unappreciated role for impaired Rac1-cofilin signaling in the aberrant spine morphology and spine density associated with FXS.
Rac1 modulates the choices of molar cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin localization to drive inner dental epithelium invagination.
The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells.
BCA3 interacts with Rac1 and augments NF-kappaB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo.
Activation of Rac1 in podocytes causes a spectrum of disease ranging from minimal change disease to focal segmental glomerulosclerosis, due to podocyte detachment from the glomerular basement membrane that is partially dependent on p38 MAPK.
a novel mechanistic model of phagosome formation spatiotemporally controlled by Rac1 switching within a phagocytic cup.
Rac1 may have vital roles in the proliferation, migration, adhesion, and odontoblastic differentiation of MDPC-23 (dental papilla) cells
Rac1 exerts a dual role in skin carcinogenesis: its activation is required for HPV-8- and UV-light induced apilloma formation but, suppresses the development of squamous cell carcinomas
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Data indicate that TNF-alpha stimulates Rac, ADAM17/TACE, and RhoA through the guanine nucleotide exchange factor (GEF)-H1.
Results suggest that Rac1 and RhoA are regulated by TGFbeta1 in the process of endothelial tube formation in collagen I gels.
Using the model of porcine aortic endothelial cells, we demonstrated that TGFbeta stimulates cellular spreading when cells are on collagen I; TGFbeta-stimulated Rac1-GTP accumulation, which was associated with increased MAPK p38 phosphorylation.
Rac1 modification by electrophiles such as 15-deoxy-delta(12,14)-prostaglandin J2 may alter redox signaling and vascular endothelial cells function.
Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity
a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.
Rac1 was activated by secretory stimuli and modulated the secretory pathway downstream of Ca2+ influx, partly through regulation of cytoskeletal organization
G protein betagamma subunits, Src kinase and the GEF Tiam1 are upstream modulators of S1P-mediated Rac1 activation, and Rac1 has a role in S1P-mediated activation of PI 3-kinase/Akt/endothelial nitric-oxide synthase signaling in vascular endothelial cells
Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
small G protein Rac1 is a key regulator of beta(3)Adrenergic receptor signaling in cultured aortic endothelial cells with potentially important implications for the pathways involved in adrenergic modulation of eNOS pathways in the vascular wall
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
our data have demonstrated a causal link between excessive Rac1 activity and podocyte injury in a dosage-dependent manner
Knockdown of fat1 in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.
ELMO-DOCK1, a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.
Our data suggest that Rac contributes to the progression of melanoma and that Tiam1 may activate Rac in nodular presentations.
Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm.
Reducing Rac1 activity in endodermal cells caused them to bypass the random migration phase.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase.
Behavior-evoked activation of Rac1-dependent forgetting has a converging function for autism-risk genes.
Rac1, a small GTPase, is specifically required in Eiger-mediated cell death. rac1 loss of function blocks Eiger-induced cell death, whereas Rac1 overexpression enhances Eiger-induced killing.
We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development
PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.
identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris
The small GTPase RAC1 is a driver of intestinal stem cell proliferation through the production of reactive oxygen species.
alphaPS1betaPS integrin controls salivary gland migration through Rac1 GTPase which downregulates E-cadherin in proximal and distal gland cells.
Rac is asymmetrically activated in germline stem cells.
These results suggest that Pak3 specifically mediates Rac1 signaling in organizing actin and myosin during Drosophila epidermal wound healing.
Apical proteins including beta(H) are negatively regulated by Rac1 activation.
Mbc is crucial for the integrity of the F-actin foci and the FCM cytoskeleton, presumably via its activation of Rac1 in these cells.
Data show that one of the two GEF domains of Trio, the Rac-specific GEF1, is essential for Trio-dependent motor axon guidance and for the genetic suppression of Notch function in motor axon patterning.
Rac may signal through Pak and LIMK to result in uniform phosphorylation of cofilin in all the outer border cells.
Recruitment of Cdc42 and Rac1 to the sites of filopodium and lamellipodium formation is Rab35 dependent and occurs by way of microtubule tracks.
Study reports that a small G protein Rac-dependent forgetting mechanism contributes to both passive memory decay and interference-induced forgetting in Drosophila.
Rac1, Rac2 and Mtl, have overlapping functions in the control of epithelial morphogenesis, myoblast fusion, and axon growth and guidance
axon growth, guidance and branching could be controlled by differential activation of Rac signalling pathways
Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila.
Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
cell migration-inducing gene 5 protein
, ras-like protein TC25
, ras-related C3 botulinum toxin substrate 1
, ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
, rho family, small GTP binding protein Rac1
, rac2 GTP-binding protein
, GTPase cRac1A
, RAS-related C3 botulinum substrate 1
, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
, ras-related C3 botulinum toxin substrate 1a (rho family, small GTP binding protein Rac1)
, CG2248 gene product from transcript CG2248-RB
, Rac GTPase
, Rac family small GTPase 1 L homeolog
, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) L homeolog