Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
Overexpression of GAS5 enhanced the sensitivity of cervical cancer cells to radiation treatment via up-regulating IER3 through miR-106b.
Our findings suggest for the first time that the increased expression of IER3 protein may promote the aggressive progression of BCa. Importantly, IER3 may be a potential prognostic marker for BCa patients.
we determined the molecular mechanism responsible for IER3 degradation, involving a ternary complex of IER3, MDM2 and FHL2, which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein
Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis.
Study characterized IEX-1's expression and function in rheumatoid arthritis synovial fibroblasts and showed that IEX-1 is highly expressed in RA-SFs and negatively regulates RA-SF activation.
interleukin-1beta (IL-1beta)-induced IER3 expression is mediated by the ERK1/2 target, transcription factor Elk-1.
findings suggest that IER3 is a putative tumor suppressor in the cervix, and the c-Ab1/p73beta/IER3 axis is a novel and crucial signaling pathway that confers etoposide chemosensitivity.
High expression of IER3 is associated with hepatocarcinoma.
In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia.
IEX-1 expression levels correlate with the severity of preeclampsia
Studied the binding effect of hcmv-miR-UL148D to the 3' untranslated region (3'UTR) of IEX-1.Results showed that only one binding site in the 3'UTR of IEX-1 was completely complementary to an 11nt sequence in the 5' terminus of hcmv-mir-UL148D.
the interference of IER3 with the PI3K/Akt-Fyn pathway represents a novel mechanism of Nrf2 regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
IEX-1 plays a role in suppression of apoptosis and protects cells by controlling sensitivity to TNFalpha under both normal and inflammatory conditions.
Altered IEX-1 expression can potentially be a new predictor of the malignant transformation and a prognostic indicator for cancer therapy.
Changes of methylation status of gene IEX-1 promoter CpG island correlates with hematologic malignancies.
IER3 plays a complex and to some extent contradictory role in cell cycle control and apoptosis. Effects of IER3 relate to an interference with certain signalling pathways
IER3 is upregulated in human PDLCs subjected to tensile stress related to mechano-induced cell cycle arrest.
Results suggest that hypertension in IEX-1 knockout mice may arise primarily from impaired cAMP signaling induced by overproduction of mitochondrial reactive oxygen species in vascular smooth muscle cells.
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice.
regulation by p53 tumor suppressor and Sp1
IER3 expression is blunted during heart failure development in a titin-deficient mouse model.
these results indicate that IER3 is a key player in expanding the pool of APC while highlighting the role of distinct effectors found in an obese microenvironment in this process
Loss of IEX-1 results in reduced VNH accompanied with a decrease in proliferation, reduced fibroblast, myofibroblast, and Ly6C staining accompanied with increased apoptosis mediated through a reduction in Vegf-A/Mcp-1 axis and Mmp-9.
IER3 supports KRASG12D-associated oncogenesis in the pancreas by sustaining ERK1/2 phosphorylation via phosphatase PP2A inhibition.
Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3).
IEX-1 has a role in activation of Erk and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells
Data suggest a role for the immediate early response gene X-1 (IEX-1) in the control of colon epithelial homeostasis.
Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 cells
Mcl-1 translocation to the nucleus is a general response to genotoxic stress that is strictly and timely controlled by IEX-1 in response to DNA damage. Loss of IEX-1 leads to genomic instability.
Null mutation of IEX-1 enhances the susceptibility of deficient mice to Leishmania major infection and aggravates inflammatory responses in comparison with wild-type control mice.
IEX-1 has roles in regulation of cell death and oncogenesis [review]
T-cell lymphomas develop in emu-IEX-1 mice.
The study reveals that IEX-1 targets the mitochondrial F1Fo-ATPase Inhibitor (IF1) for degradation, resulting in acceleration of ATP hydrolysis, concomitant with reduction in ROS production.
present data indicating that bovine IER3 is a strong regulator of immune-marker expression, specifically modulating bovine interleukin-8 activation through the NF-kappaB/IER3 pathway in response to the bovine viral diarrhea virus.
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.
PACAP-responsive gene 1 protein
, anti-death protein
, differentiation-dependent gene 2 protein
, expressed in pancreatic carcinoma
, gly96, mouse, homolog of
, immediate early protein GLY96
, immediate early response 3 protein
, immediately early gene X-1
, protein DIF-2
, radiation-inducible immediate-early gene IEX-1
, cAMP inducible gene 3
, immediate early response 3
, ATP-binding cassette, sub-family F (GCN20), member 1