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anti-Mouse (Murine) APOE Anticorps:
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Human Monoclonal APOE Primary Antibody pour CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. dans The Journal of biological chemistry 2005
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Human Polyclonal APOE Primary Antibody pour IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. dans The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Monoclonal APOE Primary Antibody pour FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. dans Archives of dermatological research 2009
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Human Polyclonal APOE Primary Antibody pour IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. dans Journal of virology 2013
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Human Polyclonal APOE Primary Antibody pour IF (p), IHC (p) - ABIN1386767
Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. dans Molecular biology reports 2014
Human Monoclonal APOE Primary Antibody pour FACS, IHC - ABIN965577
Zintzaras, Kitsios, Triposkiadis, Lau, Raman: APOE gene polymorphisms and response to statin therapy. dans The pharmacogenomics journal 2009
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Human Polyclonal APOE Primary Antibody pour IHC (p), IP - ABIN152926
Atkinson, Blumenstein, Black, Wu, Kasabov, Taylor, Cooper, North: An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia. dans Journal of lipid research 2008
Mouse (Murine) Polyclonal APOE Primary Antibody pour ID, RID - ABIN151509
Terwel, Steffensen, Verghese, Kummer, Gustafsson, Holtzman, Heneka: Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Human Polyclonal APOE Primary Antibody pour IHC (p), IHC - ABIN250408
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. dans Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) Polyclonal APOE Primary Antibody pour IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. dans Journal of agricultural and food chemistry 2015
The ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously for potential vaccine against atherosclerosis. ApoE-/- mice with oral HSP60 administration group showed a significant reduction in plaque size at the aortic root; accompanied by increased Myeloid derived suppressor cells (CD11b+Gr1+) in peripheral blood and spleen.
AIM2 (Montrer AIM2 Anticorps) overexpression and inhibition were studied in ApoE-/- mice that were fed a high-fat diet. The results showed that high fat diet increases the expression of AIM2 (Montrer AIM2 Anticorps).
Study observed that in the Apoe-deficient model of atherosclerosis, the female sex is a risk factor to develop more severe atherosclerotic lesions, although serum fat levels are not higher in females than in males. In contrast, female mice are protected from renal damage induced by the concomitant deficiency of Apoe and Itga8.
expression of CXCL16 (Montrer CXCL16 Anticorps), TIMP-1 (Montrer TIMP1 Anticorps), MMP-9 (Montrer MMP9 Anticorps), MMP-8 (Montrer MMP8 Anticorps), and LOX-1 (Montrer OLR1 Anticorps) is localized in the atherosclerotic lesions, which suggests their roles in the development of the lesions in ApoE-Knockout mice.
AMPK (Montrer PRKAA1 Anticorps) activation enhances the anti-atherogenic effects of high density lipoproteins in apoE(-/-) mice
GLP-1 receptor (Montrer GLP1R Anticorps) agonists suppress the progression of atherosclerosis by inhibiting vascular smooth muscle cell proliferation and enhancing AMP-activated protein kinase (Montrer PRKAA2 Anticorps) and cell cycle regulation in ApoE deficient mice.
results demonstrate that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-beta pathology; ApoE4 exerts a 'toxic' gain of function whereas the absence of ApoE is protective
Data (including data from studies using knockout mice) suggest that CD59a (Montrer CD59 Anticorps), CD59b (Montrer CD59 Anticorps), and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (Montrer CD59 Anticorps) (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a (Montrer CD59 Anticorps) = CD59a antigen; CD59b (Montrer CD59 Anticorps) = CD59b antigen; ApoE = apolipoprotein E)
Vitamin K2 can inhibit intimal calcification of aortic artery induced by high-fat diet in ApoE(-/-) mice via suppression of TLR2/4 expression.
the Chromogranin A (Montrer CHGA Anticorps)-derived vasostatin-2 attenuates atherosclerosis in apoE(-/-) mice and, in addition to its anti-inflammatory property, also acts as an inhibitor in monocyte/macrophage recruitment.
APOE rs405509-epsilon2/epsilon3/epsilon4 haplotypes modulate the risk of concussion susceptibility
The study of this results showed that the significantly higher fractions of subjects with pAbeta, APOE varepsilon4 allele carriers and MCI (Montrer MCIN Anticorps) subjects in the group referred from memory clinic compared to self-referred subjects.
The results of the analysis of covariance stratified by sex and serum insulin (Montrer INS Anticorps) level showed that the serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL (Montrer HSD11B1 Anticorps)-C) levels were significantly associated with changes in the serum C-peptide levels, independent of the serum insulin (Montrer INS Anticorps) level.
The results show that in cognitively normal young adults carrying APOE epsilon4 mutations had different spontaneous brain activity patterns without cerebral structural differences.
results demonstrate for the first time that ADAMTS4 (Montrer ADAMTS4 Anticorps) contributes to diet induced atherosclerosis in ApoE(-/-) mice
Overall, these findings suggest that the ability of apoE fragments to promote Abeta42 intraneuronal accumulation is specific for both the apoE4 isoform and the particular structural and thermodynamic properties of the fragment.
HtrA1 (Montrer HTRA1 Anticorps) Proteolysis of ApoE In Vitro Is Allele Selective
ApoE transcriptionally represses PPP2R5E (Montrer PPP2R5E Anticorps) and triggers demethylation of the catalytic subunit PP2AC (Montrer PPP2CA Anticorps).
The results support the hypothesis that ApoE 4 predisposes to an early development of mesial temporal lobe epilepsy with hippocampal sclerosis.
This study found that APOE3 and APOE4 targeted replacement mice demonstrate similar cognitive impairment following moderate TBI with differences reflecting the preexisting deficits in APOE4 mice at baseline.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (Montrer APOA1 Anticorps) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (Montrer HSD11B1 Anticorps) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (Montrer APOB Anticorps), ApoE, MTP (Montrer MTTP Anticorps), and LDLR (Montrer LDLR Anticorps), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (Montrer HSD11B1 Anticorps) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (Montrer APOB Anticorps)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (Montrer MTTP Anticorps)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3