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Human Polyclonal ADRBK2 Primary Antibody pour WB - ABIN390986
Rao, Rapoport, Kim: Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. dans The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009
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Human Polyclonal ADRBK2 Primary Antibody pour EIA, IHC (p) - ABIN950649
Gratacòs, Costas, de Cid, Bayés, González, Baca-García, de Diego, Fernández-Aranda, Fernández-Piqueras, Guitart, Martín-Santos, Martorell, Menchón, Roca, Sáiz-Ruiz, Sanjuán, Torrens, Urretavizcaya et al.: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and ... dans American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009
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GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB (Montrer CREB1 Anticorps) activation in promoting neuroendocrine differentiation of prostate cancer cells.
effects of GRK3 modulation appear to be specific to chemokine (Montrer CCL1 Anticorps)-mediated migration behaviors without influencing tumor cell proliferation or survival
data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6 (Montrer HDAC6 Anticorps)-induced reorganization of the vimentin (Montrer VIM Anticorps) intermediate filament network
Data indicate that CXCL12 (Montrer CXCL12 Anticorps)-induced phosphorylation at CXCR4 (Montrer CXCR4 Anticorps) S346/347 was mediated by GRK2/3.
In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene.
A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways.
mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure
we found no evidence of altered levels of acetylated histone H3 (Montrer HIST3H3 Anticorps) at the affected allele compared to the common allele
dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder
beta-arrestin 2 (Montrer ARRB2 Anticorps) and GRK2 (Montrer ADRBK1 Anticorps) colocalize with S1p2 (Montrer S1PR2 Anticorps) in developing zebrafish embryos and depletion of GRK2 (Montrer ADRBK1 Anticorps) in the S1p2 (Montrer S1PR2 Anticorps) R150H miles apart zebrafish partially rescued cardia bifida.
GRK2 (Montrer ADRBK1 Anticorps) and GRK5 (Montrer GRK5 Anticorps) control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Data suggest that a G protein-coupled receptor (Montrer GPBAR1 Anticorps) kinase, perhaps GRK2 (Montrer ADRBK1 Anticorps) or 3, functions as a vertebrate kinase for Smoothened (Montrer SMO Anticorps), promoting Hedgehog (Montrer SHH Anticorps) signal transduction during early development.
These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.
Fusion proteins containing the c-terminus of GPCR kinase 3 (GRK3ct) and either the fluorescent protein cerulean or Renilla luciferase bind to venus-labeled Gbetagamma dimers, resulting in Forster or bioluminescence resonance energy transfer.
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
adrenergic, beta, receptor kinase 2
, beta-adrenergic receptor kinase 2-like
, beta ARK2
, beta-adrenergic receptor kinase 2
, G-protein-coupled receptor kinase 3
, adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)
, G-protein coupled receptor kinase 2/3