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Syp can be quantified on circulating tumor cells and that Syp expression correlates with resistance to abiraterone and enzalutamide in castration resistant prostate cancer.
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Report of a novel SYP mutation identified in a patient with a severe neurodevelopmental disorder. Mutation does not impact on synaptic vesicles endocytosis or trafficking of common cargoes. However it is unable to support sybII retrieval in synaptophysin knockout neurons. It fully restores plasma membrane levels of sybII, suggesting that activity-dependent trafficking of sybII is specifically affected by this mutation.
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The expression of MAP2 and SYP proved most relevant to neurocognitive functioning in HIV-infected patients.
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Synaptophysin-positive epithelial proliferations suggest breast neoplasms.
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Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56.
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High synaptophysin expression is associated with neuroendocrine differentiation in colorectal cancer.
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Study reveals the presence of two selected neuronal markers, MAP-2 and SYP mRNAs and protein expression, in eutopic endometrium and in endometriotic lesions.
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Anomalous expression of all intermediate filament proteins and synaptophysin was found in significant subsets of malignant melanoma.
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Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.
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This study demonstrated that synaptophysin was significantly lower in Down syndrome with Alzheimer disease compared with Down syndrome alone and similar to sporadic Alzheimer disease.
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Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.
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The results of this study suggested that SYP may be primarily associated with ADHD-I and its genetic mechanism may be gender-specific.
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The paucity or absence of synaptophysin-positive cells in all three phenotypes of Barrett's mucosa might mirror a sequela of chronic inflammation caused by the particular pathogenic bacteria present in the immediate oesophageal microenvironment.
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Data suggest that multi-antibody assay of TTF1, Vimentin, p63 CD56, chromogranin and synaptophysin may be of special value, especially in diagnosing small biopsies.
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the author showed that, in cutaneous basal cell carcinoma, the expression of NCAM and c-KIT was high, PDGFRA was intermediate, and chromogranin A and synaptophysin was relatively low
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Depressed patients showed significant decreases in synaptophysin (SYN) and VGLUT1 expression.
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Lower levels of synaptophysin were found in the visual cortex of dementia with Lewy bodies patients compared to controls.
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Normal goblet cells found in duodenal adenomas express synaptophysin.
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The data of this study suggested that the common polymorphisms of the SYP gene appear not to play a major role in conferring susceptibility to schizophrenia.
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This is the first report of immunoreactivity for inhibin-alpha and synaptophysin in synovial sarcoma