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anti-Human CADM1 Anticorps:
anti-Mouse (Murine) CADM1 Anticorps:
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Human Polyclonal CADM1 Primary Antibody pour IF (p), IHC (p) - ABIN738351
Liu, Cui, Ao, Zhou, Zhou, Yuan, Xiang, Liu, Cao et al.: Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ... dans Toxicology and applied pharmacology 2011
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Human Polyclonal CADM1 Primary Antibody pour ICC, IF - ABIN152528
Biederer, Sara, Mozhayeva, Atasoy, Liu, Kavalali, Südhof: SynCAM, a synaptic adhesion molecule that drives synapse assembly. dans Science (New York, N.Y.) 2002
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Polyclonal CADM1 Primary Antibody pour WB - ABIN540377
Tarbé, Rio, Weidle: SMAGP, a new small trans-membrane glycoprotein altered in cancer. dans Oncogene 2004
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Human Polyclonal CADM1 Primary Antibody pour ELISA, WB - ABIN548164
Spiegel, Adamsky, Eshed, Milo, Sabanay, Sarig-Nadir, Horresh, Scherer, Rasband, Peles: A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. dans Nature neuroscience 2007
Mammalian Monoclonal CADM1 Primary Antibody pour ISt, IHC - ABIN1304990
Rollenhagen, Kuckuck, Ulm, Hartmann, Galuska, Geyer, Geyer, Mühlenhoff: Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo. dans The Journal of biological chemistry 2012
Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma
CADM1 mRNA was expressed in the intradermal lymphocytes of the patients with mycosis fungoides, but not in those of the patients with an inflammatory skin disease. CD4+ T cells of MF sample expressed CADM1 on the cell surfaces
miRNA-873 promoted Hepatocellular Carcinoma progression by targeting TSLC1.
High CADM1 expression is associated with KSHV infection.
the immunohistochemical expression of CADM1 has the potential to contribute as an auxiliary tool to the differential diagnosis between nevi and melanomas.
These findings suggest that CADM1 expression is a novel prognostic factor for peripheral T cell lymphoma, not otherwise specified
miR-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1, and an inverse correlation between miR-21 and CADM1 expression in vivo. MiR-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer
We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a useful marker of ATLL for diagnostic procedures.
miR-21 overexpression promotes cardiac fibrosis via STAT3 signaling pathway by decrease CADM1 expression, indicating miR-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation.
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (cg16962115, FDR = 1.24E-04), CADM1 (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
CADM1 mRNA expression was highly upregulated in normal tissues compared to esophageal squamous cell carcinoma tissues, indicating that the loss of CADM1 expression influenced the pathogenesis, invasion, and metastasis of ESCC.
Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix respectively. The other markers showed no statistical significance(CD151,ALP). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues
Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
High expression of CADM1 on most HTLV-1-infected cells in the face of enhanced cytotoxic T lymphocyte counterselection implies that CADM1 confers a strong benefit on the virus.
Decreased expression of TSLC1 is associated with the differentiation in ovarian epithelial cancer. TSLC1 might be used as a molecular marker of severity in early stage ovarian cancer, and to help differentiating benign and malignant ovarian tumors.
Suppression of tumorigenesis by CADM1 may be mediated by the Rb-E2F1 pathway.
CADM1 prevents squamous cell carcinoma progression by reducing STAT3 activity
Decreased expression of TSLC1 is correlated with the malignancy of non-muscle invasive bladder cancer tissues and low TSLC1 expression may serve as a predictor for bladder cancer recurrence and progression.
CADM1 deletion is associated with neuroblastoma and ganglioneuroma.
Hypermethylation of CADM1 gene may be highly associated with the development of cervical cancer.
alternative splicing can give rise to both shedding-susceptible and shedding-resistant CADM1 (cell adhesion molecule 1) variant proteins.
SynCAM1, Neuroligin-1B and Neuroligin-2A were overexpressed in newborn neurons in the dentate gyrus of 7- to 9-week-old mice. SynCAM1 increased the morphological maturation of dendritic spines and mossy fiber terminals while Neuroligin-1B increased spine density. In contrast, Neuroligin-2A increased both spine density and size as well as GABAergic innervation and resulted in a drastic increase of neuronal survival.
NF-kB mediated upregulation of CADM1 was identified as a mechanism of TNFalpha induced migration.
The results of this study demonstrate that the synapse-organizing adhesion molecule SynCAM 1 has pronounced effects on neuronal connectivity in the hippocampal CA3 area.
Cadm1 is a direct target of NFATc1, which is induced by RANKL through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner.
Data show that cell adhesion molecule 1 (SynCAM 1) generally prolongs the lifetime of spines.
This experiments show that the survival rate of adult-generated neurons is increased by overexpressing SynCAM 1
Our study reveals a novel mechanism of chronic NF-kappaB activation by CADM1 in HTLV-1 infected cells
Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 cells and identifies the presence of polysialic acid-NRP2 in microglia
CADM1 appeared to sustain gap junctional intercellular communication among alpha-cells via homophilic binding and, based on this action, CADM1 appears to prevent excessive secretion of glucagon from alpha-cells.
This study demonistrated that SynCAM 1 in the synaptic organization of the rod visual pathway and provide evidence for novel roles of synaptic adhesion in the structural and functional integrity of ribbon synapses.
Necl-2 co-localizes with ErbB4 in hippocampus and and regulates ErbB4 signaling in cultured neurons.
TGF-beta1 is a potent cytokine that provides an effective mechanism in controlling Necl-2 expression in the testis via Smad-dependent gene repression and clathrin-mediated endocytosis.
Loss of SynCAM1 modulates cocaine effects on spine structures in the nucleus accumbens.
The bone volume fraction did not differ between the CADM1 knockout mice and the wild type mice for both 8-week old and 11-week old mice.
Cadm1 is indeed a bona fide tumor suppressor gene and provide new insights into genetic partners that co-operate in tumorigenesis when Cadm1-expression is lost.
These results indicated that CADM1 was a novel osteoblastic adhesion molecule that is expressed transiently during osteoblastic maturation, and a useful diagnostic marker for osteosarcoma cells.
Cadm1 specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum.
Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo.
Epigenetic silencing complexity in the promoter region of Cadm1 is not only defined by DNA hypermethylation, but high nucleosome occupancy, altered nucleosome positioning and 'bivalent' histone modifications.
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
, TSLC1/Nectin-like 2/IGSF4
, immunoglobulin superfamily member 4
, immunoglobulin superfamily, member 4
, immunoglobulin superfamily, member 4D variant 1
, immunoglobulin superfamily, member 4D variant 2
, nectin-like 2
, nectin-like protein 2
, spermatogenic immunoglobulin superfamily
, synaptic cell adhesion molecule
, truncated CADM1 protein
, tumor suppressor in lung cancer 1
, cell adhesion molecule 1
, cell adhesion molecule 1 transcript variant 8abc
, immunoglobulin superfamily member 4A
, immunosuperfamily protein Bl2
, immunoglobulin superfamily, member 4A
, secretory isoform of TSLC1
, tumor suppressor in lung cell-1