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anti-Human CADM1 Anticorps:
anti-Mouse (Murine) CADM1 Anticorps:
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Human Polyclonal CADM1 Primary Antibody pour IF (p), IHC (p) - ABIN738351
Liu, Cui, Ao, Zhou, Zhou, Yuan, Xiang, Liu, Cao et al.: Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ... dans Toxicology and applied pharmacology 2011
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Human Polyclonal CADM1 Primary Antibody pour ICC, IF - ABIN152528
Biederer, Sara, Mozhayeva, Atasoy, Liu, Kavalali, Südhof: SynCAM, a synaptic adhesion molecule that drives synapse assembly. dans Science (New York, N.Y.) 2002
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Mammalian Monoclonal CADM1 Primary Antibody pour ISt, IHC - ABIN1304990
Rollenhagen, Kuckuck, Ulm, Hartmann, Galuska, Geyer, Geyer, Mühlenhoff: Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo. dans The Journal of biological chemistry 2012
miRNA-873 promoted Hepatocellular Carcinoma progression by targeting TSLC1.
High CADM1 expression is associated with KSHV infection.
the immunohistochemical expression of CADM1 has the potential to contribute as an auxiliary tool to the differential diagnosis between nevi and melanomas.
These findings suggest that CADM1 expression is a novel prognostic factor for peripheral T cell lymphoma, not otherwise specified
miR (Montrer MLXIP Anticorps)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1, and an inverse correlation between miR (Montrer MLXIP Anticorps)-21 and CADM1 expression in vivo. MiR (Montrer MLXIP Anticorps)-21 overexpression is attributed to MYCN (Montrer MYCN Anticorps)-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer
We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a useful marker of ATLL for diagnostic procedures.
miR (Montrer MLXIP Anticorps)-21 overexpression promotes cardiac fibrosis via STAT3 (Montrer STAT3 Anticorps) signaling pathway by decrease CADM1 expression, indicating miR (Montrer MLXIP Anticorps)-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation.
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (Montrer LYST Anticorps) (cg16962115, FDR = 1.24E-04), CADM1 (cg21933078, FDR = 1.22E-02) and NFATC1 (Montrer NFATC1 Anticorps) (cg06784563, FDR = 1.46E-02)
CADM1 mRNA expression was highly upregulated in normal tissues compared to esophageal squamous cell carcinoma tissues, indicating that the loss of CADM1 expression influenced the pathogenesis, invasion, and metastasis of ESCC.
Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix (Montrer SP7 Anticorps) respectively. The other markers showed no statistical significance(CD151 (Montrer CD151 Anticorps),ALP (Montrer ALP Anticorps)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues
SynCAM1, Neuroligin-1B and Neuroligin-2A were overexpressed in newborn neurons in the dentate gyrus of 7- to 9-week-old mice. SynCAM1 increased the morphological maturation of dendritic spines and mossy fiber terminals while Neuroligin-1B increased spine density. In contrast, Neuroligin-2A increased both spine density and size as well as GABAergic innervation and resulted in a drastic increase of neuronal survival.
NF-kB mediated upregulation of CADM1 was identified as a mechanism of TNFalpha (Montrer TNF Anticorps) induced migration.
The results of this study demonstrate that the synapse-organizing adhesion molecule (Montrer NCAM1 Anticorps) SynCAM 1 has pronounced effects on neuronal connectivity in the hippocampal CA3 (Montrer CA3 Anticorps) area.
Cadm1 is a direct target of NFATc1 (Montrer NFATC1 Anticorps), which is induced by RANKL (Montrer TNFSF11 Anticorps) through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner.
Data show that cell adhesion molecule 1 (SynCAM 1) generally prolongs the lifetime of spines.
This experiments show that the survival rate of adult-generated neurons is increased by overexpressing SynCAM 1
Our study reveals a novel mechanism of chronic NF-kappaB (Montrer NFKB1 Anticorps) activation by CADM1 in HTLV-1 infected cells
Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 (Montrer Vcan Anticorps) cells and identifies the presence of polysialic acid-NRP2 (Montrer NRP2 Anticorps) in microglia
CADM1 appeared to sustain gap junctional intercellular communication among alpha-cells via homophilic binding and, based on this action, CADM1 appears to prevent excessive secretion of glucagon (Montrer GCG Anticorps) from alpha-cells.
This study demonistrated that SynCAM 1 in the synaptic organization of the rod visual pathway and provide evidence for novel roles of synaptic adhesion in the structural and functional integrity of ribbon synapses.
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
, TSLC1/Nectin-like 2/IGSF4
, immunoglobulin superfamily member 4
, immunoglobulin superfamily, member 4
, immunoglobulin superfamily, member 4D variant 1
, immunoglobulin superfamily, member 4D variant 2
, nectin-like 2
, nectin-like protein 2
, spermatogenic immunoglobulin superfamily
, synaptic cell adhesion molecule
, truncated CADM1 protein
, tumor suppressor in lung cancer 1
, cell adhesion molecule 1
, cell adhesion molecule 1 transcript variant 8abc
, immunoglobulin superfamily member 4A
, immunosuperfamily protein Bl2
, immunoglobulin superfamily, member 4A
, secretory isoform of TSLC1
, tumor suppressor in lung cell-1