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Human Polyclonal SUPT6H Primary Antibody pour ChIP, ICC - ABIN4355771
Kronemann, Hagemeier, Cygnar, Phillips, Bresnahan: Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV. dans Journal of virology 2010
Show all 5 Pubmed References
Human Polyclonal SUPT6H Primary Antibody pour IP - ABIN251024
Cygnar, Hagemeier, Kronemann, Bresnahan: The cellular protein SPT6 is required for efficient replication of human cytomegalovirus. dans Journal of virology 2012
Altogether, these results indicate that a complex containing LEDGF/p75 (Montrer PSIP1 Anticorps), Iws1, and Spt6 participates in regulating postintegration steps of HIV latency.
identified fibronectin (Montrer FN1 Anticorps), a component of the extracellular matrix and a mesenchymal marker, as a transcriptional target of Pak1 (Montrer PAK1 Anticorps) signaling
Spt6 is a unique histone chaperone capable of regulating the histone epigenetic state of both AID targets and the AID locus.
These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 (Montrer PAAF1 Anticorps) and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.
Abolishing UL69's ability to interact with the SPT6 protein inhibited human cytomegalovirus replication.
Knockdown of Spt6 resulted in severe reduction of class switch recombination in the endogenous Ig locus in B cells.
Reults establish that human Spt6 (hSpt6) is a classic transcription elongation factor (Montrer TSFM Anticorps) that enhances the rate of RNA polymerase II (Montrer Pol II Anticorps) elongation.
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.
These data indicate that, through cooperation with PolII (Montrer Pol II Anticorps) and KDM6A (Montrer KDM6A Anticorps), Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
Thus binding of Spt6 to Ser2 (Montrer JAG2 Anticorps)-P RNAPII (Montrer Pol II Anticorps) provides a cotranscriptional mechanism to recruit Iws1, REF1/Aly (Montrer THOC4 Anticorps), and associated mRNA processing, surveillance, and export factors to responsive genes.
recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1
The elongation factors Pandora/Spt6 and Foggy/Spt5 (Montrer SUPT5H Anticorps) promote transcription in the zebrafish embryo. (Pandora/Spt6)
Spt6 is essential for the transcriptional response to activation of the Notch (Montrer NOTCH1 Anticorps) pathway.
Acts to stimulate transcriptional elongation by RNA polymerase II (By similarity).
, tat-CT2 protein
, tat-cotransactivator 2 protein
, transcription elongation factor SPT6
, suppressor of Ty 6 homolog
, protein pandora
, suppressor of Ty 6 homolog (S. cerevisiae)
, Spt6 gene product
, SUPT6H,-like protein to suppressor of ty 6
, transcription elongation factor SPT6-like
, hypothetical protein