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Atoh8 is dispensible for zebrafish development under standard laboratory conditions.
ATOH8, GATA4, and FOG2 associate in a single complex
These findings raise the possibility that ATOH8 is a pivotal regulator in nasopharyngeal carcinoma tumorigenesis
Data demonstrated that ATOH8 expression was upregulated in colorectal cancer (CRC (Montrer CALR Protéines)) patients, and seems to increase the malignancy potential of CRC (Montrer CALR Protéines).
calcineurin mediates the subcellular localization of ATOH8, which reveals the regulation of ATOH8 transcriptional activity by calcium signaling via calcineurin.
Regeneration marker ATOH8 contributes to muscle cell differentiation in healthy and diseased human muscle tissue.
ATOH8 appears to be a tumor suppressor that induces stem-cell features and chemoresistance in HCC (Montrer FAM126A Protéines) cells.
Data show that in ATOH8 was hosted in one chromosome which is a fusion product of two orthologous chromosomes in non-human. primates.
ATOH8 is an important transcriptional regulator of hepcidin (Montrer HAMP Protéines) in beta-thalassemia.
Atoh8 modulates activation of the endocrine program.
It has observed Math6 expression in various organs at early and late stages of mouse development, which illustrates the involvement of Math6 in multiple developmental events.
results reveal distinctive transcriptional properties of Atoh8 within the atonal-related bHLH family that may be associated with the acquisition of new biological functions.
Neurogenin3 (Montrer NEUROG3 Protéines) can trigger the conversion of Math6 from a poorly transcribed bivalent to an active monovalent state in vitro, hence providing a mechanism whereby Neurogenin3 (Montrer NEUROG3 Protéines) may activate Math6 in endocrine progenitors
Math6 may participate in kidney development and may be a permissive factor for podocyte differentiation.
Bmp6 (Montrer BMP6 Protéines), Smad7 (Montrer SMAD7 Protéines), Id1 (Montrer ID1 Protéines), and Atoh8 transcripts are significantly modulated by the dietary iron content; activation of Smad7 (Montrer SMAD7 Protéines), Id1 (Montrer ID1 Protéines), and Atoh8 transcription by iron requires Smad4 (Montrer SMAD4 Protéines).
results demonstrate that Math6 is indispensable for early embryonic development and indicate a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes
Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity).
protein atonal homolog 8
, atonal homolog 8 (Drosophila)
, atonal homolog 8
, atonal homolog 6
, basic helix loop helix transcription factor 6
, basic helix-loop-helix transcription factor 6
, class A basic helix-loop-helix protein 21
, helix-loop-helix protein hATH-6
, helix-loop-helix protein mATH-6