anti-Souris MSH2 anticorps pour Immunofluorescence (Paraffin-embedded Sections)

Recommended MSH2 Antibody

Antigène
MSH2 Anticorps
  • COCA1
  • FCC1
  • HNPCC
  • HNPCC1
  • LCFS2
  • AI788990
  • wu:fc06b02
  • wu:fc13e09
  • zgc:55333
  • msh2
  • mutS homolog 2
  • mutS homolog 2 (E. coli)
  • mutS homolog 2 L homeolog
  • MutS protein homolog 2
  • MSH2
  • Msh2
  • msh2
  • msh2.L
Épitope
AA 80-130
14
12
12
11
8
7
6
5
5
4
3
3
3
3
2
2
1
1
1
1
Reactivité
Humain, Souris
170
65
43
10
7
6
5
4
3
3
3
2
1
1
1
1
1
Hôte
Lapin
111
57
3
Clonalité
Polyclonal
Conjugué
Inconjugué
5
4
4
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
123
63
57
45
33
25
19
15
12
9
7
3
2
1
Options

Images

N° du produit ABIN672816
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Clonality References Details
1 ABIN907068 IF (p) Alexa Fluor 647 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN907066 IF (p) Alexa Fluor 488 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN907065 IF (p) Alexa Fluor 350 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN907067 IF (p) Alexa Fluor 555 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN672821 IF (p) Cy5.5 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN672823 IF (p) FITC Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN672822 IF (p) Cy7 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN672820 IF (p) Cy5 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN672819 IF (p) Cy3 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN2804314 IF (p) Alexa Fluor 594 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN5007052 IF (p) Alexa Fluor 750 Rabbit IgG AA 80-130 Polyclonal 0
1 ABIN5007051 IF (p) Alexa Fluor 680 Rabbit IgG AA 80-130 Polyclonal 0

General

Antigène MSH2 Anticorps
Épitope AA 80-130
(14), (12), (12), (11), (8), (7), (6), (5), (5), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivité Humain, Souris
(170), (65), (43), (10), (7), (6), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Hôte Lapin
(111), (57), (3)
Clonalité
Polyclonal
Conjugué Inconjugué
(5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(123), (63), (57), (45), (33), (25), (19), (15), (12), (9), (7), (3), (2), (1)
Fournisseur

Détail du produit

Détail du antigène Information d'application Stockage Images
Purification Purified by Protein A.
Immunogène KLH conjugated synthetic peptide derived from human MSH-2
Isotype IgG

Détail du antigène

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Antigène
Sujet

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

Subcellular location: Nucleus

Synonyms: FCC1, COCA1, HNPCC, LCFS2, HNPCC1, DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2, MSH2

ID gène 4436
UniProt P43246
Pathways Réparation de l'ADN, Production of Molecular Mediator of Immune Response

Information d'application

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Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Stockage

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Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months

Images

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Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-MSH2 (AA 80-130) antibody (ABIN672816) Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti MSH2 Po...