anti-Rat (Rattus) MSH2 anticorps pour Immunohistochemistry (Paraffin-embedded Sections)

Recommended MSH2 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
MSH2 Anticorps
  • COCA1
  • FCC1
  • HNPCC
  • HNPCC1
  • LCFS2
  • AI788990
  • wu:fc06b02
  • wu:fc13e09
  • zgc:55333
  • msh2
  • mutS homolog 2
  • mutS homolog 2 (E. coli)
  • mutS homolog 2 L homeolog
  • MutS protein homolog 2
  • MSH2
  • Msh2
  • msh2
  • msh2.L
Épitope
AA 337-583
15
12
12
11
8
7
6
5
5
5
4
3
3
2
2
2
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
172
61
35
11
7
6
5
4
3
3
3
2
2
1
1
1
1
Hôte
Lapin
110
60
3
Clonalité
Polyclonal
Conjugué
Inconjugué
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
127
66
58
48
38
25
21
17
13
9
7
3
2
1
Options
Fournisseur
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N° du produit (Fournisseur)
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N° du produit ABIN3043885
$ 280.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
19 ABIN3031884 ICC IHC (p) WB Rabbit IgG AA 337-583 Connectez-vous pour afficher Polyclonal 0
7 ABIN2890014 ELISA IF IHC IHC (p) Rabbit IgG AA 541-590 Connectez-vous pour afficher Polyclonal 0
1 ABIN2743034 ICC IHC IHC (p) WB Rabbit IgG AA 337-583 Connectez-vous pour afficher Polyclonal 0
1 ABIN127110 IHC (p) IP WB Rabbit Connectez-vous pour afficher Polyclonal 0

General

Antigène MSH2 Anticorps
Épitope AA 337-583
(15), (12), (12), (11), (8), (7), (6), (5), (5), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivité Humain, Souris, Rat (Rattus)
(172), (61), (35), (11), (7), (6), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Hôte Lapin
(110), (60), (3)
Clonalité
Polyclonal
Conjugué Inconjugué
(4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(127), (66), (58), (48), (38), (25), (21), (17), (13), (9), (7), (3), (2), (1)
Pubmed 1 référence disponible
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Détail du produit

Détail du antigène Information d'application Stockage Référence Images
Fonction Rabbit IgG polyclonal antibody for DNA mismatch repair protein Msh2(MSH2) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for DNA mismatch repair protein Msh2(MSH2) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: mutS homolog 2
Protein Name: DNA mismatch repair protein Msh2
Purification Immunogen affinity purified.
Immunogène E.coli-derived human MSH2 recombinant protein (Position: Q337-N583). Human MSH2 shares 94% and 93% amino acid (aa) sequence identity with mouse and rat MSH2, respectively.
Isotype IgG

Détail du antigène

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Antigène
Sujet DNA mismatch repair protein Msh2, also known as MutS protein homolog 2 or MSH2, is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2 which forms aheterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair. It has been found that MSH2 may also be a coactivator of ESR1-dependent gene expression.

Synonyms: BAT26 antibody|COCA 1 antibody|COCA1 antibody|DNA mismatch repair protein Msh2 antibody|FCC 1 antibody|FCC1 antibody|hMSH2 antibody|HNPCC 1 antibody|HNPCC antibody|HNPCC1 antibody|LCFS2 antibody|MSH 2 antibody|Msh2 antibody|MSH2_HUMAN antibody|MutS homolog 2 antibody|MutS homolog 2 colon cancer nonpolyposis type 1 antibody|MutS protein homolog 2 antibody
ID gène 4436
UniProt P43246
Pathways Réparation de l'ADN, Production of Molecular Mediator of Immune Response

Information d'application

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Indications d'application WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, The detection limit for MSH2 is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Commentaires

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Restrictions For Research Use only

Stockage

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Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Référence

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Produit citée dans:

Zhang, Yue, Wang, Li, Xin, Pang, Zheng, Xie: "Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth." dans: Biomedicine & pharmacotherapy, Vol. 67, Issue 2, pp. 97-102, 2014

Images

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Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-MSH2 (AA 337-583) antibody (ABIN3043885) Anti- MSH2 Picoband antibody,ICC ICC: SMMC Cell
Immunohistochemistry (IHC) image for anti-MSH2 (AA 337-583) antibody (ABIN3043885) Anti- MSH2 Picoband antibody, IHC(P) IHC(P): Mouse Intestine Tissue
Immunohistochemistry (IHC) image for anti-MSH2 (AA 337-583) antibody (ABIN3043885) Anti- MSH2 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue
Western Blotting (WB) image for anti-MSH2 (AA 337-583) antibody (ABIN3043885) Anti- MSH2 Picoband antibody, Western blotting All lanes: Anti MSH2 at 0.5ug/ml Lane...
Immunohistochemistry (IHC) image for anti-MSH2 (AA 337-583) antibody (ABIN3043885) Anti- MSH2 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue