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the S. pombe ICln protein is required for optimal production of the spliceosomal snRNPs and for efficient splicing in vivo
functional interaction between ICln and HSPC038
RioK1 (Montrer RIOK1 Anticorps), a new interactor of protein arginine methyltransferase 5 (PRMT5 (Montrer PRMT5 Anticorps)), competes with pICln for binding and modulates PRMT5 (Montrer PRMT5 Anticorps) complex composition and substrate specificity.
revealed an increase of ICln in the mesothelioma cell membrane under hypotonic conditions, an event possibly related to the activation of Cl(-) channels
ICln interacts with integrin alphaIIbbeta3 and regulates platelet activation.
Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin (Montrer PLEK Anticorps) homology (PH) domain family of proteins and interacts with LSm4 (Montrer LSM4 Anticorps), a protein involved in splicing and mRNA degradation.
Lsm10 (Montrer LSM10 Anticorps) and Lsm11 (Montrer LSM11 Anticorps), which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 (Montrer PRMT5 Anticorps) and SMN (Montrer STMN1 Anticorps) complexes
ICln associates with the cell membrane after cell swelling
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6.
chloride channel regulatory protein
, chloride channel, nucleotide sensitive 1A
, chloride conductance regulatory protein ICln
, chloride ion current inducer protein
, methylosome subunit pICln
, reticulocyte pICln
, reticulocyte protein ICln
, chloride channel current inducer
, chloride channel regulator
, Clns 1a
, chloride channel, nucleotide-sensitive, 1A
, swelling-induced chloride conductance regulatory protein
, swelling dependent chloride channel