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SCN2A Produits

(Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Catégories

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].

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Catégories SCN2A en vedette

SCN2A Anticorps

High quality antibodies with extensive validation data.

SCN2A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SCN2A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application IHC, ELISA
Validations
  • (2)
N° du produit ABIN7192279
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application IHC, ELISA, WB
Validations
  • (2)
N° du produit ABIN6263502
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application IHC, WB, IF, IP, ICC
Validations
  • (3)
N° du produit ABIN7043641
Quantité 25 μL
Fiche technique Fiche technique

SCN2A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1319275
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3076691
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3076688
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits SCN2A

Gazina, Leaw, Richards, Wimmer, Kim, Aumann, Featherby, Churilov, Hammond, Reid, Petrou: "'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour." dans: Human molecular genetics, Vol. 24, Issue 5, pp. 1457-68, (2015) (PubMed).

Wildburger, Ali, Hsu, Shavkunov, Nenov, Lichti, LeDuc, Mostovenko, Panova-Elektronova, Emmett, Nilsson, Laezza: "Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain." dans: Molecular & cellular proteomics : MCP, Vol. 14, Issue 5, pp. 1288-300, (2015) (PubMed).

Hamada, Kole: "Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 18, pp. 7272-86, (2015) (PubMed).

Wimmer, Harty, Richards, Phillips, Miyazaki, Nukina, Petrou: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." dans: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).

Camargos, Bosmans, Rego, Mourão, Schwartz: "The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0128578, (2015) (PubMed).

Liu, Deng, Wang, Zhang, Luo, Yan, Su, Liu: "KCNE2 modulates cardiac L-type Ca(2+) channel." dans: Journal of molecular and cellular cardiology, Vol. 72, pp. 208-18, (2014) (PubMed).

Baek, Rubinstein, Scheuer, Trimmer: "Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures." dans: The Journal of biological chemistry, Vol. 289, Issue 22, pp. 15363-73, (2014) (PubMed).

Wang, Hooks, Sun: "Thorough GABAergic innervation of the entire axon initial segment revealed by an optogenetic 'laserspritzer'." dans: The Journal of physiology, Vol. 592, Issue Pt 19, pp. 4257-76, (2014) (PubMed).

Li, Tian, Scalmani, Frassoni, Mantegazza, Wang, Yang, Wu, Shu: "Action potential initiation in neocortical inhibitory interneurons." dans: PLoS biology, Vol. 12, Issue 9, pp. e1001944, (2014) (PubMed).

Tian, Wang, Ke, Guo, Shu: "Molecular identity of axonal sodium channels in human cortical pyramidal cells." dans: Frontiers in cellular neuroscience, Vol. 8, pp. 297, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à SCN2A

sodium voltage-gated channel alpha subunit 2 (SCN2A), sodium channel protein type 2 subunit alpha (LOC100217927), sodium channel protein type 2 subunit alpha (LOC100389294), sodium channel protein type 2 subunit alpha (LOC100484218), sodium channel, voltage-gated, type II, alpha (Scn2a), sodium voltage-gated channel alpha subunit 2 (Scn2a), sodium channel protein type 2 subunit alpha (LOC478773), sodium channel, voltage-gated, type II, alpha subunit (SCN2A), 6430408L10, A230052E19Rik, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, Na(v)1.2, NAC2, NachII, Nav1.2, RII/RIIA, RNSCPIIR, SCN, Scn2a, SCN2A, SCN2A1, SCN2A2, Scn2a2, ScpII

Protein level used designations for SCN2A

  • sodium channel, voltage-gated, type II, alpha subunit
  • sodium channel protein type 2 subunit alpha-like
  • sodium channel, voltage-gated, type II, alpha polypeptide 1
  • RIIA sodium channel protein
  • alternative product
  • sodium channel protein brain II subunit alpha
  • sodium channel protein type 2 subunit alpha
  • sodium channel protein type II subunit alpha
  • sodium channel protein, brain II subunit alpha
  • sodium channel voltage-gated type II alpha polypeptide
  • sodium channel, voltage-gated, type 2, alpha 1 polypeptide
  • sodium channel, voltage-gated, type 2, alpha 1 subunit
  • voltage-gated sodium channel subunit alpha Nav1.2
  • HBSC II
  • sodium channel protein, brain type 2 alpha subunit
  • sodium channel, voltage-gated, type II, alpha 1 polypeptide
  • sodium channel, voltage-gated, type II, alpha 2 polypeptide
  • voltage-gated sodium channel subtype II
  • voltage-gated sodium channel II
  • sodium channel protein
  • sodium channel, type II, alpha polypeptide
  • sodium channel, voltage-gated, type II, alpha 1
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