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SCN8A Produits

(Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

Catégories

This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

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Catégories SCN8A en vedette

SCN8A Anticorps

High quality antibodies with extensive validation data.

SCN8A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SCN8A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (3)
N° du produit ABIN520023
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
N° du produit ABIN7075647
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC
Validations
  • (4)
N° du produit ABIN2776200
Quantité 100 μL
Fiche technique Fiche technique

SCN8A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1319283
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3076703
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3076701
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits SCN8A

Wimmer, Harty, Richards, Phillips, Miyazaki, Nukina, Petrou: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." dans: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).

Baalman, Marin, Ho, Godoy, Cherian, Robertson, Rasband: "Axon initial segment-associated microglia." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 5, pp. 2283-92, (2015) (PubMed).

Hirono, Ogawa, Misono, Zollinger, Trimmer, Rasband, Misonou: "BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 18, pp. 7082-94, (2015) (PubMed).

Camargos, Bosmans, Rego, Mourão, Schwartz: "The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0128578, (2015) (PubMed).

King, Manning, Trimmer: "A unique ion channel clustering domain on the axon initial segment of mammalian neurons." dans: The Journal of comparative neurology, Vol. 522, Issue 11, pp. 2594-608, (2014) (PubMed).

Chang, Zollinger, Susuki, Sherman, Makara, Brophy, Cooper, Bennett, Mohler, Rasband: "Glial ankyrins facilitate paranodal axoglial junction assembly." dans: Nature neuroscience, Vol. 17, Issue 12, pp. 1673-81, (2014) (PubMed).

Baalman, Cotton, Rasband, Rasband: "Blast wave exposure impairs memory and decreases axon initial segment length." dans: Journal of neurotrauma, Vol. 30, Issue 9, pp. 741-51, (2013) (PubMed).

Sun, Wagnon, Mahaffey, Briese, Ule, Frankel: "Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice." dans: The Journal of physiology, Vol. 591, Issue Pt 1, pp. 241-55, (2013) (PubMed).

Ruff, Ye, Legasto, Stribbell, Wang, Zhang, Fehlings et al.: "Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and ..." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 29, pp. 11899-915, (2013) (PubMed).

Xiao, Bosch, Nerbonne, Ornitz: "FGF14 localization and organization of the axon initial segment." dans: Molecular and cellular neurosciences, Vol. 56, pp. 393-403, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à SCN8A

sodium voltage-gated channel alpha subunit 8 (SCN8A), sodium voltage-gated channel alpha subunit 8 (Scn8a), sodium channel, voltage-gated, type VIII, alpha (Scn8a), AI853486, C630029C19Rik, CERIII, CIAT, dmu, EIEE13, MED, med, mnd-2, mnd2, NaCh6, Nav1.6, nmf2, nmf58, nmf335, nur14, PN4, seal

Protein level used designations for SCN8A

  • hNa6/Scn8a voltage-gated sodium channel
  • sodium channel protein type 8 subunit alpha
  • voltage-gated sodium channel subunit alpha Nav1.6
  • Na+ channel
  • PN4
  • naCh6
  • peripheral nerve protein type 4
  • sodium channel 6
  • sodium channel protein type VIII subunit alpha
  • sodium channel voltage-gated type VIII alpha polypeptide
  • sodium channel, voltage-gated, type 8, alpha polypeptide
  • sodium channel, voltage-gated, type 8, alpha subunit
  • sodium channel, voltage-gated, type VIII, alpha polypeptide
  • ataxia 3
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