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Based on this finding and on the finding that actin remodeling is required for hepatic secretion, the authors further confirmed that WDR1 is a phosphoprotein that regulates secretion.
Deficiency of the actin regulator WDR1 in human subjects is associated with a paucity of B-cell progenitors in the bone marrow and lack of switched memory B cells in the periphery. WDR1 missense mutations lead to aberrant assembly of both T- and B-cell immunologic synapses.
WDR1 is an EYA3-specific substrate, which implies that EYA3 is a key modulator of the cytoskeletal reorganization
Functions of WDR1 in actin filament dynamics and cytoskeletal regulation in health and disease have been described. (Review)
STAT3 bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells.
MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration.
homozygous missense L153F/L293F mutation in the actin regulatory gene WDR1 causes a new autoinflammatory disease in humans, with periodic fevers, immunodeficiency, and intermittent thrombocytopenia (PFIT).
These data suggest that WDR1 plays an important role in suppressing platelet activity, where it alters the actin cytoskeleton dynamics, and downregulation of WDR1 may contribute to the platelet-mediated pathogenesis of cardiovascular disease.
Mutations in WDR1 affect neutrophil morphology, motility, and function, causing a novel primary immunodeficiency
A/A" genotype of rs12498927 was associated with increased risk of gout.
Identify positive correlations between WDR1 and CLNK gene polymorphisms in Chinese-Tibetan gout populations.
Demonstrate a previously unanticipated role of Aip1 in regulating the structure and remodeling of intestinal epithelial junctions and early steps of epithelial morphogenesis.
When maternal environmental tobacco smoke was considered, fifteen of 135 single nucleotide polymorphism (SNPs) mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance.
Data suggest that anti-WD repeat domain 1 (WDR1) antibody could be applied for serological screening of papillary thyroid carcinoma (PTC) and undifferentiated thyroid carcinoma (UTC), and could be an efficient and inexpensive biomarker.
WD repeat-containing protein 1 was confirmed as being significantly overexpressed in interstitial fluid from ovarian carcinomas compared to healthy ovarian tissue.
Studies suggest that vascular endothelial growth factor may be responsible for upregulated P-glycoprotein expression.
The QKI RNA-binding proteins regulate oligodendrocyte differentiation by modulating the expression of AIP-1.
Studies indicate that CUL4 uses a large beta-propeller protein, DDB1, as a linker to interact with a subset of WD40 proteins.
AIP1/WDR1 could abort the severing/disassembly activity somewhat still carried out due to phosphorylated ADF/cofilin
Data indicates that Aip1 plays an important role in directional cell migration by restricting the stimulus-induced membrane protrusion to one direction via promoting cofilin activity.
Wdr1 gene deletion in germ cells can influence early ovarian function of mice and lead to premature ovarian failure.
Findings demonstrate that WDR1 is a critical factor for normal structure and function of adult mouse heart.
Following platelets spreading on fibrinogen substrate, Wdr-1 translocates to the cytoskeleton in association with cofilin-1. In Wdr-1-deficient platelets, cofilin-1 is aberrantly localized throughout the cytoplasm and there is no significant change following adhesion to fibrinogen substrate.
essential for talin-induced activation of alphaIIbbeta3 during platelet activation
WDR1 interacts with Lim domain kinase 1 (LIMK1), a well known phosphorylation kinase of Cofilin.
Wdr1 and cofilin/destrin-mediated actomyosin remodelling are essential for generating or maintaining cortical tension within the developing epidermal sheet and driving the cell shape and planar orientation changes.
Wdr1-regulated actin dynamics play essential roles in heart function in mice. F-actin accumulations caused by Wdr1 deletion result in disruption of sarcomeric structure.
studies establish an essential requirement for Wdr1 in megakaryocytes and neutrophils
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
, WD repeat-containing protein 1
, actin-interacting protein 1
, WD40 repeat protein 1
, WD repeat protein 1