Aperçu des produits pour anti-p53 (TP53) Anticorps

Human Tumor Protein P53 (TP53) interaction partners

1. Data suggest that H2O2 regulates cell death in granulosa cells via the ROS (Montrer ROS1 Anticorps)-JNK (Montrer MAPK8 Anticorps)-p53 pathway.

2. About half of HPV-negative penile cancers are driven by oncogenic activation of TP53, while a quarter is induced by loss of TP53 tumor suppressor function

3. Our data showed that relative TP53 mRNA expression was not significantly altered in both tissues exposed to lasers. For ATM (Montrer ATM Anticorps), relative mRNA expression in skin tissue was not significantly altered, but in muscle tissue, laser exposure increased relative ATM (Montrer ATM Anticorps) mRNA expression. Low-level red and infrared laser radiations alter ATM (Montrer ATM Anticorps) mRNA expression related to DNA stability in skeletal muscle tissue.

4. we identified a novel mutant p53:c-Abl cytoplasmic signaling complex that promotes MDA-MB-231 cell growth and highlights the contextual cues that confer oncogenic activity to c-Abl in breast cancer

5. Results showed that the high levels of HDAC11 (Montrer HDAC11 Anticorps) and lower levels of p53 were detected in pituitary tumor cells. A negative correlation was detected between the data of HDAC11 (Montrer HDAC11 Anticorps) and p53.

6. ENTPD5 (Montrer ENTPD5 Anticorps) is a mediator of mutant p53 gain of function activity in clonogenic growth, architectural tissue remodeling, migration, invasion, and lung colonization in lung cancer and its mouse models

7. COP1 (Montrer CARD16 Anticorps) forms complex with p53 protein nd plays a role in p53 down-regulation.

8. We conclude that p53 protein accumulation, detected by immunohistochemistry in aggregates of cells, is a significant predictor of malignant progression in patients with Barrett's metaplasia

9. TP53 mutant cancer cells had elevation of ribonucleotide reductase subunit 1 (RRM1 (Montrer RRM1 Anticorps)) and 2 (RRM2 (Montrer RRM2 Anticorps)), which was reduced by inhibition of mTORC1.

10. Transcriptome analysis of MUC16 (Montrer MUC16 Anticorps) KD showed a downregulation (P = 0.005) of TSPYL5 (Montrer TSPYL5 Anticorps) gene, which encodes for a testis-specific (Montrer THEG Anticorps) Y-like protein...Also, MUC16 (Montrer MUC16 Anticorps) overexpression induced cisplatin and gemcitabine resistance by downregulation of p53

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

2. SIRT1 (Montrer SIRT1 Anticorps), p53 and NF-kappaB (Montrer NFKB1 Anticorps) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

4. Data indicate that higher hepatic glucocorticoid receptor (GR (Montrer NR3C1 Anticorps)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (Montrer SP1 Anticorps)).

5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (Montrer MAPK14 Anticorps) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

6. role of transcription factor p53 and the metabolic hormone leptin (Montrer LEP Anticorps), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (Montrer BCL2 Anticorps) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

9. Suppressive effect of FSH (Montrer BRD2 Anticorps) and LH on p53 expression and caspase-3 (Montrer CASP3 Anticorps) activity with parallel increase in bcl-2 (Montrer BCL2 Anticorps) expression and increased P production was observed.

10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (Montrer MAPK14 Anticorps) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (Montrer MAPK14 Anticorps) plays a role by way of stimulating NF-kappaB (Montrer NFKB1 Anticorps), p53 and caspase-3 (Montrer CASP3 Anticorps) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (Montrer BCL2 Anticorps) proteins.

4. Chronically activated, monomeric PDGFRA (Montrer PDGFRA Anticorps) induced prolonged activation of Akt (Montrer AKT1 Anticorps) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) interaction partners

1. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

2. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

3. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

4. results suggest that trim69 (Montrer TRIM69 Anticorps) participates in tp53-mediated apoptosis during zebrafish development.

5. mutant Mdm2 (Montrer MDM2 Anticorps) was unable to rescue a p53-induced apoptotic phenotype.

6. C/ebpalpha (Montrer CEBPA Anticorps) plays a role in liver growth regulation via the p53 pathway.

7. Results demonstrate a novel role of Klf8 (Montrer KLF8 Anticorps), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

8. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

9. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (Montrer MDM2 Anticorps) pathway.

10. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (Montrer HDAC1 Anticorps) and DNMT3A (Montrer DNMT3A Anticorps) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (Montrer AKT1 Anticorps) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

1. The p53 R72P polymorphism did not differentially affect the physiological response to ionizing radiation in mice.

2. c-Abl (Montrer ABL1 Anticorps) phosphorylation of Mdm2 (Montrer MDM2 Anticorps) has a role in regulation of p53 tumor suppression and bone marrow failure

3. Astrocyte-endothelial cell transition could also be modulated by miR (Montrer MLXIP Anticorps)-194, a microRNA downstream of p53 that affects expression of genes regulating angiogenesis.

4. This work documents the important role for p53 in the heart as a master regulator of the cardiac transcriptome.

5. p53-dependent SIRT6 (Montrer SIRT6 Anticorps) expression protects cells from Abeta42-induced DNA damage.

6. Here, we provide novel insights into treatment response for the antiandrogen abiraterone by analyses of a genetically engineered mouse (GEM) model with combined inactivation of Trp53 and Pten, which are frequently comutated in human castration-resistant prostate cancer (CRPC).

7. LIN41 (Montrer TRIM71 Anticorps) interacts with p53, controls its abundance by ubiquitination and antagonizes p53-dependent pro-apoptotic and pro-differentiation responses. In vivo, lack of LIN41 (Montrer TRIM71 Anticorps) is associated with upregulation of Grhl3 (Montrer GRHL3 Anticorps) and widespread caspase-3 (Montrer CASP3 Anticorps) activation, 2 downstream effectors of p53 with essential roles in neural tube closure.

8. Here, we show that cabozantinib rapidly eradicates invasive, poorly differentiated PTEN/p53-deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from tumor cells, including CXCL12 (Montrer CXCL12 Anticorps) and HMGB1 (Montrer HMGB1 Anticorps), resulting in robust infiltration of neutrophils into the tumor.

9. Here we show that radiation-resistant cells and tumors derived from a Pten/Trp53-deficient mouse model of advanced prostate cancer are rendered radiation sensitive following treatment with NanoOlaparib, a lipid-based injectable nanoformulation of olaparib.

10. our study supports the presence of a p53-independent mechanism of cell death and cell cycle arrest resulting from DHX9 inhibition. our results support the feasibility of targeting DHX9 as a chemotherapeutic approach in p53-deficient tumors.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (Montrer CASP3 Anticorps), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

1. Expression of p53 and Ki67 (Montrer MKI67 Anticorps) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) interaction partners

1. miR (Montrer MYLIP Anticorps)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) interaction partners

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.