Aperçu des produits pour anti-p53 (TP53) Anticorps

Human Tumor Protein P53 (TP53) interaction partners

1. the TP53 R72P genotype may serve as a clinical prognostic factor in lung carcinomas

2. Positive p53 and negative p16 staining was seen in 4 (17%) cases histologically suggestive of differentiated vulvar intraepithelial neoplasia

3. RUNX2 (Montrer RUNX2 Anticorps) is one of the promising molecular targets for the treatment of the patients with pancreatic cancer regardless of their p53 status[review]

4. monosomal karyotype (p = 0.04) and not TP53 mutations (p = 0.07) predicted leukemic transformation

5. Genetic alterations in TP53 are a critical factor in determining the use of a combination treatment of doxorubicin and Src (Montrer SRC Anticorps) inhibitors.

6. degradation of p53 by E6 protein of high risk human papillomavirus is also suggested as one of the mechanisms which attenuate p53 responses in oral carcinogenesis[review]

7. miR (Montrer MLXIP Anticorps)-24 is up-regulated in age-related cataracts. It appears to enhance lens epithelial cell apoptosis and inhibit cell proliferation by directly targeting p53, suggesting that the miR (Montrer MLXIP Anticorps)-24-p53 pathway may play a critical role in cataractogenesis.

8. p53 expression was knocked down using p53 small interfering RNA, which suppressed microRNA22 expression and increased IL6 mRNA expression, inhibited Bax protein expression and caspase3 activity, and induced Cyr61 expression in HEB cells.

9. Negative correlation was detected between the severity of cases and P53 copy numbers.

10. Single nucleotide polymorphism rs1042522 of the TP53 gene is not significantly correlated with the risk of male infertility.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

2. SIRT1 (Montrer SIRT1 Anticorps), p53 and NF-kappaB (Montrer NFKB1 Anticorps) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

4. Data indicate that higher hepatic glucocorticoid receptor (GR (Montrer NR3C1 Anticorps)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (Montrer SP1 Anticorps)).

5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (Montrer MAPK14 Anticorps) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

6. role of transcription factor p53 and the metabolic hormone leptin (Montrer LEP Anticorps), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (Montrer BCL2 Anticorps) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

9. Suppressive effect of FSH (Montrer BRD2 Anticorps) and LH on p53 expression and caspase-3 (Montrer CASP3 Anticorps) activity with parallel increase in bcl-2 (Montrer BCL2 Anticorps) expression and increased P production was observed.

10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (Montrer MAPK14 Anticorps) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (Montrer MAPK14 Anticorps) plays a role by way of stimulating NF-kappaB (Montrer NFKB1 Anticorps), p53 and caspase-3 (Montrer CASP3 Anticorps) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (Montrer BCL2 Anticorps) proteins.

4. Chronically activated, monomeric PDGFRA (Montrer PDGFRA Anticorps) induced prolonged activation of Akt (Montrer AKT1 Anticorps) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) interaction partners

1. Nkx2.5 signaling via activation of Nkx2.5-Calr (Montrer CALR Anticorps)-p53 signaling pathway results in cardiac dysfunction and hyperglycemia-induced cardiomyopathy.

2. In the hsf4 (Montrer HSF4 Anticorps)(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas (Montrer FASN Anticorps) and bax (Montrer BAX Anticorps) mRNA into the mutant embryos, we directly proved that HSF4 (Montrer HSF4 Anticorps) promotes lens fiber cell differentiation by activating p53 and its downstream regulators

3. p53-target genes in Danio rerio have been identified.

4. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

5. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

6. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

7. results suggest that trim69 (Montrer TRIM69 Anticorps) participates in tp53-mediated apoptosis during zebrafish development.

8. mutant Mdm2 (Montrer MDM2 Anticorps) was unable to rescue a p53-induced apoptotic phenotype.

9. C/ebpalpha (Montrer CEBPA Anticorps) plays a role in liver growth regulation via the p53 pathway.

10. Results demonstrate a novel role of Klf8 (Montrer KLF8 Anticorps), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (Montrer HDAC1 Anticorps) and DNMT3A (Montrer DNMT3A Anticorps) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (Montrer AKT1 Anticorps) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

1. Comparison of lineage-related p53 knockout and wild-type clones reveals a minor role of p53 in suppressing cell expansion in lung adenomas. In contrast, p53 loss promotes both the initiation and expansion of low-grade pancreatic intraepithelial neoplasia, likely through differential expression of the p53 regulator p19ARF.

2. The neuroprotective effects of p53/microRNA22 may regulate inflammation and apoptosis in in subarachnoid hemorrhage.

3. wild-type p53 exerts a dominant tumor-suppressive effect on mutant tumors, as all genotypes were similarly sensitive to its restoration in vivo

4. Data demonstrate a causative role for TRP53 mutants in development of chemoresistant lung cancer.

5. Activation of p53 blocks neural differentiation of miRNA-deficient pluripotent stem cells.

6. p53 mediates the regulation of bile acid disposition and attenuates cholic acid-induced cholestasis in mice

7. Data demonstrates that p53 inhibits OSX (Montrer SP7 Anticorps) binding to their responsive Sp1 (Montrer SP1 Anticorps)/GC-rich (Montrer RELB Anticorps) sites in the promoters of their osteogenic target genes, such as IBSP (Montrer IBSP Anticorps) or COL1A1 (Montrer COL1A1 Anticorps).

8. A summary of current knowledge of p53-mediated tumor-suppressive mechanisms gleaned from in vivo studies in mouse models (review).

9. Increased Cdc7 (Montrer CDC7 Anticorps)-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma.

10. Aging mouse models have revealed the complexity of the p53-Mdm2 (Montrer MDM2 Anticorps) axis and have solidly placed the p53 network as being key to many aspects of both pathological aging conditions and normal aging (review).

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (Montrer CASP3 Anticorps), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

1. Expression of p53 and Ki67 (Montrer MKI67 Anticorps) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) interaction partners

1. miR (Montrer MYLIP Anticorps)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) interaction partners

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.