Aperçu des produits pour anti-p53 (TP53) Anticorps

Human Tumor Protein P53 (TP53) interaction partners

1. results showed that a) alterations of the p53 and Rb pathways are associated with high proliferation of tumor cells in BUC and b) high expression of cell-cycle proteins is associated with adverse histopathological parameters of these tumors

2. Moreover, under positive p53 expression, low expression of ATM[ataxia telangiectasia mutated] was highly predictive of poor survival in ACC[Adenoid cystic carcinoma] (p=0.017). CONCLUSION: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic marker for assessing survival rate in patients with ACC [Adenoid cystic carcinom]of the salivary glands.

3. These results suggest that the wild type p53 plays a role in regulating ZIP14 (Montrer SLC39A14 Anticorps), but not DMT1 (Montrer DMRT1 Anticorps) in HepG2 cells.

4. these results suggested that Aloin may induce apoptosis in A549 cells via the ROSmitogen activated protein kinase (Montrer CDK7 Anticorps) signaling pathway, with p53 phosphorylation. These results implicate Aloin as a potential therapeutic agent for the treatment of lung cancer.

5. Data demonstrates that p53 inhibits OSX (Montrer MID1 Anticorps) binding to their responsive Sp1 (Montrer PSG1 Anticorps)/GC-rich (Montrer RELB Anticorps) sites in the promoters of their osteogenic target genes, such as IBSP (Montrer IBSP Anticorps) or COL1A1 (Montrer COL1A1 Anticorps).

6. A two-hit loss involving VHL (Montrer VHL Anticorps) predicted for clear-cell renal cell carcinoma (Montrer MOK Anticorps)(ccRCC ) and a better prognosis, whereas mutations in PTEN, TP53, or RELN (Montrer RELN Anticorps) predicted for Sarcomatoid clear-cell renal cell carcinoma (Montrer MOK Anticorps) and worse prognosis.

7. Nongenotoxic p53 activation suppresses mTOR (Montrer FRAP1 Anticorps) activity. Moreover, p53 reactivation via RG7388, a second-generation MDM2 (Montrer MDM2 Anticorps) inhibitor, strongly enhances the in vivo antitumor activity of temsirolimus

8. Low TP53 expression is associated with hepatocellular carcinoma.

9. Our results suggest that TP53 may be linked with type 2 diabetes mellitus (T2DM). The fluctuations of serum TP53 level may reflect metabolic and oxidative stress associated with chronic hyperglycaemia

10. Vorinostat synergizes with AZD1775 in head and neck squamous cell carcinoma (HNSCC)cells with mutant p53 in vitro and in vivo A strategy combining HDAC (Montrer HDAC3 Anticorps) and WEE1 (Montrer WEE1 Anticorps) inhibition deserves further clinical investigation in patients with advanced HNSCC.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

2. SIRT1 (Montrer SIRT1 Anticorps), p53 and NF-kappaB (Montrer NFKB1 Anticorps) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

4. Data indicate that higher hepatic glucocorticoid receptor (GR (Montrer NR3C1 Anticorps)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (Montrer SP1 Anticorps)).

5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (Montrer MAPK14 Anticorps) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

6. role of transcription factor p53 and the metabolic hormone leptin (Montrer LEP Anticorps), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (Montrer BCL2 Anticorps) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

9. Suppressive effect of FSH (Montrer BRD2 Anticorps) and LH on p53 expression and caspase-3 (Montrer CASP3 Anticorps) activity with parallel increase in bcl-2 (Montrer BCL2 Anticorps) expression and increased P production was observed.

10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

2. These results suggest that p38 MAPK (Montrer MAPK14 Anticorps) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (Montrer MAPK14 Anticorps) plays a role by way of stimulating NF-kappaB (Montrer NFKB1 Anticorps), p53 and caspase-3 (Montrer CASP3 Anticorps) activation.

3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (Montrer BCL2 Anticorps) proteins.

4. Chronically activated, monomeric PDGFRA (Montrer PDGFRA Anticorps) induced prolonged activation of Akt (Montrer AKT1 Anticorps) and suppressed the level of p53.

5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Zebrafish Tumor Protein P53 (TP53) interaction partners

1. Nkx2.5 signaling via activation of Nkx2.5-Calr (Montrer CALR Anticorps)-p53 signaling pathway results in cardiac dysfunction and hyperglycemia-induced cardiomyopathy.

2. In the hsf4 (Montrer HSF4 Anticorps)(null) fish, both p53 and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53, fas (Montrer FASN Anticorps) and bax (Montrer BAX Anticorps) mRNA into the mutant embryos, we directly proved that HSF4 (Montrer HSF4 Anticorps) promotes lens fiber cell differentiation by activating p53 and its downstream regulators

3. p53-target genes in Danio rerio have been identified.

4. Data indicate that genetic inhibition of autophagy promotes tumorigenesis in tumor protein p53 (tp53) mutant.

5. Data suggest that the sensitivity of p53 to expression of an editing-defective tRNA synthetase has a critical role in promoting genome integrity and organismal homeostasis.

6. Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development

7. results suggest that trim69 (Montrer TRIM69 Anticorps) participates in tp53-mediated apoptosis during zebrafish development.

8. mutant Mdm2 (Montrer MDM2 Anticorps) was unable to rescue a p53-induced apoptotic phenotype.

9. C/ebpalpha (Montrer CEBPA Anticorps) plays a role in liver growth regulation via the p53 pathway.

10. Results demonstrate a novel role of Klf8 (Montrer KLF8 Anticorps), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (Montrer HDAC1 Anticorps) and DNMT3A (Montrer DNMT3A Anticorps) are reported.

2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

3. PI3K/Akt (Montrer AKT1 Anticorps) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

1. Activation of p53 blocks neural differentiation of miRNA-deficient pluripotent stem cells.

2. p53 mediates the regulation of bile acid disposition and attenuates cholic acid-induced cholestasis in mice

3. Data demonstrates that p53 inhibits OSX (Montrer SP7 Anticorps) binding to their responsive Sp1 (Montrer SP1 Anticorps)/GC-rich (Montrer RELB Anticorps) sites in the promoters of their osteogenic target genes, such as IBSP (Montrer IBSP Anticorps) or COL1A1 (Montrer COL1A1 Anticorps).

4. A summary of current knowledge of p53-mediated tumor-suppressive mechanisms gleaned from in vivo studies in mouse models (review).

5. Increased Cdc7 (Montrer CDC7 Anticorps)-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma.

6. Aging mouse models have revealed the complexity of the p53-Mdm2 (Montrer MDM2 Anticorps) axis and have solidly placed the p53 network as being key to many aspects of both pathological aging conditions and normal aging (review).

7. In myoblasts silenced for the expression of muscle regulatory transcription factor MyoD (Montrer MYOD1 Anticorps), tumor suppressor p53 binding to the PUMA (Montrer BBC3 Anticorps) promoter is diminished in response to culture in differentiation medium.

8. Study provides evidence that high expression of CLDN6 (Montrer CLDN6 Anticorps) confers chemoresistance on breast cancer which is mediated by GSTP1 (Montrer GSTP1 Anticorps), the activity of which is regulated by p53.

9. AKI was associated with the upregulation of several known p53 target genes. This was attenuated in p53-KO mice. In human renal tubular epithelial cell line, vancomycin induced p53 accumulation. p53 was associated with the development of VAN (Montrer SLC11A2 Anticorps)-induced AKI through upregulation of miR (Montrer MLXIP Anticorps)-192-5p.

10. Recent work in a TP53(-/-)BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

2. PP2A:B56{epsilon}, a substrate of caspase-3 (Montrer CASP3 Anticorps), regulates p53-dependent and p53-independent apoptosis during development.

3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

1. Expression of p53 and Ki67 (Montrer MKI67 Anticorps) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

Goat Tumor Protein P53 (TP53) interaction partners

1. miR (Montrer MYLIP Anticorps)-34c expression is p53-dependent in dairy goat male germline stem cells.[p53]

Medaka Tumor Protein P53 (TP53) interaction partners

1. p53 is not essential for tissue self-renewal in developing brain.

2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.