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Human CDK2 Protein expressed in Wheat germ - ABIN1348934
Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". dans Molecular and cellular biology 2006
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CDK2 may have key functions in neuroblastoma (Montrer ARHGEF16 Protéines) progression by regulating the expression of neoplastic genes.
The authors show that human Cyclin (Montrer PCNA Protéines)-Dependent-Kinases (CDKs) target the RAD9 (Montrer RAD9A Protéines) subunit of the 9-1-1 checkpoint clamp (Montrer PDZK1 Protéines) on Thr292, to modulate DNA damage checkpoint activation. Thr292 phosphorylation on RAD9 (Montrer RAD9A Protéines) creates a binding site for Polo-Like-Kinase1 (PLK1), which phosphorylates RAD9 (Montrer RAD9A Protéines) on Thr313.
this study suggests that CDK2 and CDK9 (Montrer CDK9 Protéines) are potential therapeutic targets in Neuroblastoma (Montrer ARHGEF16 Protéines) (NB) and that abrogating CDK2 and CDK9 (Montrer CDK9 Protéines) activity by small molecules like dinaciclib is a promising strategy and a treatment option for NB patients
LINC00958 acts as an oncogenic gene in the gliomagenesis through miR (Montrer MLXIP Protéines)-203-CDK2 regulation, providing a novel insight into glioma tumorigenesis.
These compounds bind CDK2/ Cyclin A (Montrer CCNA2 Protéines), inhibit its kinase activity, compete with substrate binding, but not with ATP, and dock onto the T-loop of CDK2. The best compound also binds CDK4 (Montrer CDK4 Protéines) and CDK4 (Montrer CDK4 Protéines)/Cyclin D1 (Montrer CCND1 Protéines), but not CDK1 (Montrer CDK1 Protéines).
CDK2 contributes to S81-AR phosphorylation and transactivation while CDK4 (Montrer CDK4 Protéines) was not shown to be involved in this process.
Our findings provide a rationale for clinical use of Bcl-2 (Montrer BCL2 Protéines) family inhibitors in combination with CDK2 inhibitors for treatment of Mcl-1 (Montrer MCL1 Protéines)-dependent colorectal tumours associated with expression of Bcl-2 (Montrer BCL2 Protéines), Bcl-XL (Montrer BCL2L1 Protéines) and Bcl-w (Montrer BCL2L2 Protéines) proteins. In addition, we have shown potential of CDK2 inhibitors for treatment of tumours expressing R273H mutant p53 (Montrer TP53 Protéines).
Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 (Montrer CCNE1 Protéines) and AKT2 (Montrer AKT2 Protéines) Overexpression of Cyclin E1 (Montrer CCNE1 Protéines) and AKT (Montrer AKT1 Protéines) isoforms, in addition to mutant TP53 (Montrer TP53 Protéines), imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of high-grade serous ovarian cancer
WHSC1L1 (Montrer WHSC1L1 Protéines) and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 (Montrer CDC6 Protéines) and CDK2, implying that WHSC1L1 (Montrer WHSC1L1 Protéines) directly regulates the transcription of these gene
Findings suggest that ERK1/2-mediated Cdk2/cyclin A (Montrer CCNA2 Protéines) signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
evidence that cyclin A1 (Montrer CCNA1 Protéines)-associated activity is a mediator of apoptosis and that cyclin A1 (Montrer CCNA1 Protéines)/Cdk2 is sufficient to induce apoptosis
Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres.
CDK2 phosphorylates polyQ-AR specifically at Ser (Montrer SIGLEC1 Protéines)(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.
CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals
Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (Montrer CCNE1 Protéines)/cdk2 promoting hepatocarcinogenesis.
This approach allowed us to determine the identity of cyclin E (Montrer CCNE1 Protéines) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (Montrer PCNA Protéines) E1and cyclin E2 (Montrer CCNE2 Protéines))and its associated kinase, Cdk2, in different mouse organs.
RingoA (Montrer SPDYA Protéines) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (Montrer FOXO3 Protéines) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (Montrer CDK1 Protéines), wee1 (Montrer WEE1 Protéines), p21 (Montrer CDKN1A Protéines), PCNA (Montrer PCNA Protéines) and cdk2, but only weakly influences cyclin B1 (Montrer CCNB1 Protéines), cyclin B2 (Montrer CCNB2 Protéines) and cyclin E1 (Montrer CCNE1 Protéines) expression.
PI3-kinase (Montrer PIK3CA Protéines) and Akt (Montrer AKT1 Protéines) participate in insulin (Montrer INS Protéines) stimulation of p34cdc2 (Montrer CDK1 Protéines) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (Montrer UHRF1 Protéines) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (Montrer CCNA2 Protéines) during early vertebrate development
cyclin D1 (Montrer CCND1 Protéines), CDK2 and CDK4 (Montrer CDK4 Protéines) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
our results indicate that an ATM (Montrer ATM Protéines)-P53 (Montrer TP53 Protéines)-P21 (Montrer CDKN1A Protéines) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, Cyclin-dependent kinase 2-interacting protein
, cyclin-dependent kinase 2 interacting protein
, cyclin-dependent kinase 2-interacting protein
, MGC84068 protein
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2