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Human CDK2 Protein expressed in Wheat germ - ABIN1348934
Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". dans Molecular and cellular biology 2006
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CDK2 mutation is not associated with non-obstructive azoospermia.
Proteomics and phosphoproteomics analyses identified CDK2 as a driver of resistance to both BRAF (Montrer BRAF Protéines) and Hsp90 (Montrer HSP90 Protéines) inhibitors and its expression is regulated by the transcription factor MITF (Montrer MITF Protéines) upon XL888 treatment of melanoma cells.
identified a new phosphorylation-based substrate recognition mechanism of PTPN12 (Montrer PTPN12 Protéines) by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK2 and HER2 (Montrer ERBB2 Protéines) pathways
CDK2 gene is a strong candidate gene for type-2 diabetes. CDK2 gene is located in a risk area composed of 4 blocks in strong LD around the type-2 diabetes SNP rs2069408. CDK2 overexpression inhibits the association of insulin receptor (Montrer INSR Protéines) to the microtubule components, tubulin (Montrer TUBB Protéines) alpha and tubulin beta (Montrer TUBB Protéines). Physical association of the insulin receptor (Montrer INSR Protéines) complex with CDK2 is inhibited by the expression of tyrosine phosphatase PTPLAD1 (Montrer PTPLAD1 Protéines).
ATM and CDK2 control the chromatin remodeling activity of CSB in the regulation of double strand break repair pathway choice.
Among these genes, STAT3 (Montrer STAT3 Protéines) and CDK2 were significantly associated with recurrence. Further study suggested that inhibition of CDK2 reduced invasion of Pca (Montrer FLVCR1 Protéines) cell lines. The invasion ability was rescued after reintroduction of CDK2.
The roles of the CDK2/SIRT5 (Montrer SIRT5 Protéines) axis in gastric cancer.
CDK2 may have key functions in neuroblastoma (Montrer ARHGEF16 Protéines) progression by regulating the expression of neoplastic genes.
The authors show that human Cyclin (Montrer PCNA Protéines)-Dependent-Kinases (CDKs) target the RAD9 (Montrer RAD9A Protéines) subunit of the 9-1-1 checkpoint clamp (Montrer PDZK1 Protéines) on Thr292, to modulate DNA damage checkpoint activation. Thr292 phosphorylation on RAD9 (Montrer RAD9A Protéines) creates a binding site for Polo-Like-Kinase1 (PLK1), which phosphorylates RAD9 (Montrer RAD9A Protéines) on Thr313.
this study suggests that CDK2 and CDK9 (Montrer CDK9 Protéines) are potential therapeutic targets in Neuroblastoma (Montrer ARHGEF16 Protéines) (NB) and that abrogating CDK2 and CDK9 (Montrer CDK9 Protéines) activity by small molecules like dinaciclib is a promising strategy and a treatment option for NB patients
study suggests that hepatocellular carcinoma initiation specifically depends on CcnE1 (Montrer CCNE1 Protéines) and Cdk2, while HCC (Montrer FAM126A Protéines) progression requires expression of any E-cyclin (Montrer PCNA Protéines), but no Cdk2.
Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres.
CDK2 phosphorylates polyQ-AR specifically at Ser (Montrer SIGLEC1 Protéines)(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.
CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals
Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (Montrer CCNE1 Protéines)/cdk2 promoting hepatocarcinogenesis.
This approach allowed us to determine the identity of cyclin E (Montrer CCNE1 Protéines) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (Montrer PCNA Protéines) E1and cyclin E2 (Montrer CCNE2 Protéines))and its associated kinase, Cdk2, in different mouse organs.
RingoA (Montrer SPDYA Protéines) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (Montrer FOXO3 Protéines) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (Montrer CDK1 Protéines), wee1 (Montrer WEE1 Protéines), p21 (Montrer CDKN1A Protéines), PCNA (Montrer PCNA Protéines) and cdk2, but only weakly influences cyclin B1 (Montrer CCNB1 Protéines), cyclin B2 (Montrer CCNB2 Protéines) and cyclin E1 (Montrer CCNE1 Protéines) expression.
PI3-kinase (Montrer PIK3CA Protéines) and Akt (Montrer AKT1 Protéines) participate in insulin (Montrer INS Protéines) stimulation of p34cdc2 (Montrer CDK1 Protéines) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (Montrer UHRF1 Protéines) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (Montrer CCNA2 Protéines) during early vertebrate development
cyclin D1 (Montrer CCND1 Protéines), CDK2 and CDK4 (Montrer CDK4 Protéines) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
evidence that cyclin A1 (Montrer CCNA1 Protéines)-associated activity is a mediator of apoptosis and that cyclin A1 (Montrer CCNA1 Protéines)/Cdk2 is sufficient to induce apoptosis
our results indicate that an ATM (Montrer ATM Protéines)-P53 (Montrer TP53 Protéines)-P21 (Montrer CDKN1A Protéines) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2