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Human PPP2CA Protein expressed in Wheat germ - ABIN1316010
Hung, Wang, Chen, Chu, Hsiao, Tai, Chao, Yu, Shiau, Chen: SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A. dans Oncotarget 2016
Suspension survival mediated by PP2A (Montrer PPP2R4 Protéines)-STAT3 (Montrer STAT3 Protéines)-Col (Montrer HDAC1 Protéines) XVII determines tumor initiation and metastasis in cancer stem cells.
alpha-Syn bound to PP2A (Montrer PPP2R4 Protéines) Calpha (Montrer PRKACA Protéines) by the hydrophobic interaction and upregulated its activity. Blocking the hydrophobic domain of alpha-Syn or hydrophilic mutation on the residue I123 in PP2A (Montrer PPP2R4 Protéines) Calpha (Montrer PRKACA Protéines) all reduced PP2A (Montrer PPP2R4 Protéines) activity upregulation by alpha-Syn.
The results showed SNPs near PPP2CA were associated with decreased expression of PPP2CA mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE.
This study demonstrated an association of PPP2CA (rs10491322 and rs7704116) with systemic lupus erythematosus susceptibility in a Chinese Han population. Furthermore, the minor allele of PPP2CA rs10491322 as a risk factor was correlated with immunologic disorders for systemic lupus erythematosus.
RAB9 (Montrer RAB9A Protéines) competes with the catalytic subunit PPP2CA in binding to PPP2R1A (Montrer PPP2R1A Protéines). This competitive association has an important role in controlling the PP2A (Montrer PPP2R4 Protéines) catalytic activity.
Results show that miR (Montrer MLXIP Protéines)-199b is a tumor suppressor emerges as a potential contributing mechanism to inhibit PP2A (Montrer PPP2R4 Protéines) via PP2A (Montrer PPP2R4 Protéines) inhibitor SET (SET) overexpression in metastatic colorectal cancer (mCRC).
Data show that protein phosphatase-2A (PP2A (Montrer PPP2R4 Protéines)) was upregulated in lung adenocarcinoma cell lines that were transfected with midline 1 (Montrer MID1 Protéines) E3 ubiquitin-protein ligase (Montrer UBE2K Protéines) (MID1 (Montrer MID1 Protéines))-siRNA, suggesting MID1 (Montrer MID1 Protéines) negatively regulates PP2A (Montrer PPP2R4 Protéines) in lung adenocarcinoma.
B55alpha (Montrer PPP2R2A Protéines)-PP2A (Montrer PPP2R4 Protéines) mutations in acute myeloid leukemia (Montrer BCL11A Protéines) have roles in leukemogenesis by promoting AKT (Montrer AKT1 Protéines) T308 phosphorylation and sensitivity to AKT (Montrer AKT1 Protéines) inhibitor-induced growth arrest
This work has significantly advanced our understanding of the RACK1 (Montrer GNB2L1 Protéines)/PP2A (Montrer PPP2R4 Protéines) complex and suggests a pro-carcinogenic role for the RACK1 (Montrer GNB2L1 Protéines)/PP2A (Montrer PPP2R4 Protéines) interaction. This work suggests that approaches to target the RACK1 (Montrer GNB2L1 Protéines)/PP2A (Montrer PPP2R4 Protéines) complex are a viable option to regulate PP2A (Montrer PPP2R4 Protéines) activity and identifies a novel potential therapeutic target in the treatment of breast cancer.
Moreover, PP2Acalpha2-overexpressed cells demonstrated increased expression of IGBP1 (Montrer IGBP1 Protéines), activated mTORC1 signaling to reduce basal autophagy and increased anchorage-independent growth. Our study provides new insights into the complex mechanisms of PP2A (Montrer PPP2R4 Protéines) regulation.
Results indicate that Dlx5 (Montrer DLX5 Protéines) and Runx2 (Montrer RUNX2 Protéines) are critical factors for the upregulated Osterix (Montrer SP7 Protéines) expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.
Data (including data from studies in transgenic mice) suggest that Esr1 signaling promotes activation of Pp2a; here, central activation of Pp2a during estrogen replacement therapy is involved in prevention of menopause-induced obesity and glucose intolerance (that is, induced by lack of membrane-initiated Esr1 signaling). (Esr1 = estrogen receptor 1; Pp2a = protein phosphatase 2A)
The data also suggest that H2A.Z (Montrer H2AFZ Protéines) restricts transcription, which is moderated by ANP32e (Montrer ANP32E Protéines) at the promoter and gene bodies of expressed genes. Thus, ANP32e (Montrer ANP32E Protéines), through inhibition of PP2A (Montrer PPP2R2B Protéines), is required for nucleosomal inclusion of H2A.Z (Montrer H2AFZ Protéines) and the regulation of gene expression
PP2A (Montrer PPP2R2B Protéines) is a target of piperine, which induces autophagy in a rotenone-induced Parkinson's disease model
In vitro, SCF (Montrer KITLG Protéines) induced the phosphorylation of p38 MAPK (Montrer MAPK14 Protéines) and cofilin (Montrer CFL1 Protéines), leading to the migration of cardiac stem cells.
We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.
data show that Fyn (Montrer FYN Protéines) kinase is activated after TLR4 (Montrer TLR4 Protéines) triggering and exerts an important negative control on LPS (Montrer TLR4 Protéines)-dependent TNF (Montrer TNF Protéines) production in mast cells controlling the inactivation of PP2Ac and activation of PKCalpha (Montrer PKCa Protéines)/beta necessary for the secretion of TNF (Montrer TNF Protéines) by VAMP3 (Montrer VAMP3 Protéines)(+) carriers
endogenous siRNA (PTEN-sh-3p21) cleaved from PTEN-sh within PTEN mRNA 3'UTR modulates PPP2CA and PTEN at the post-transcriptional level in liver cells
PP2A (Montrer PPP2R2B Protéines) activation both limited and prevented inflammation and tissue injury in two direct injury models of Acute respiratory distress syndrome.
PP2A (Montrer PPP2R2B Protéines) regulates kinetochore-microtubule attachment during meiosis I in oocyte.
changes in PP2A (Montrer PPP2R2B Protéines) activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function
The findings demonstrate an endothelial VEGF (Montrer VEGFA Protéines) resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A (Montrer PPP2R2B Protéines)-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.
PP2A (Montrer PPP2R2B Protéines) and AIP1 (Montrer PDCD6IP Protéines) cooperatively induce activation of ASK1 (Montrer MAP3K5 Protéines)-JNK (Montrer MAPK8 Protéines) signaling and vascular endothelial cell apoptosis.
Hsp27 (Montrer HSPB1 Protéines) is dephosphorylated by PP2A (Montrer PPP2R2B Protéines) in dorsal ruffles, in non-caveolar lipid raft microdomains.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
, protein phosphatase 2A catalytic subunit, alpha isoform
, replication protein C
, serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
, protein phosphatase 2a, catalytic subunit, alpha isoform
, protein phosphatase 2, catalytic subunit, alpha isoform
, protein phosphatase-2A-alpha
, protein phosphatase 2A alpha subunit
, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
, type 2A protein phosphatase catalytic subunit
, protein phosphatase 2, catalytic subunit, beta isoform
, protein phosphatase 2, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like