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Human PPP2CA Protein expressed in Wheat germ - ABIN1316010
Hung, Wang, Chen, Chu, Hsiao, Tai, Chao, Yu, Shiau, Chen: SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A. dans Oncotarget 2016
In vitro, SCF (Montrer KITLG Protéines) induced the phosphorylation of p38 MAPK (Montrer MAPK14 Protéines) and cofilin (Montrer CFL1 Protéines), leading to the migration of cardiac stem cells.
We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.
data show that Fyn (Montrer FYN Protéines) kinase is activated after TLR4 (Montrer TLR4 Protéines) triggering and exerts an important negative control on LPS (Montrer TLR4 Protéines)-dependent TNF (Montrer TNF Protéines) production in mast cells controlling the inactivation of PP2Ac and activation of PKCalpha (Montrer PKCa Protéines)/beta necessary for the secretion of TNF (Montrer TNF Protéines) by VAMP3 (Montrer VAMP3 Protéines)(+) carriers
endogenous siRNA (PTEN-sh-3p21) cleaved from PTEN-sh within PTEN mRNA 3'UTR modulates PPP2CA and PTEN at the post-transcriptional level in liver cells
PP2A (Montrer PPP2R2B Protéines) activation both limited and prevented inflammation and tissue injury in two direct injury models of Acute respiratory distress syndrome.
PP2A (Montrer PPP2R2B Protéines) regulates kinetochore-microtubule attachment during meiosis I in oocyte.
these results suggest that inhibiting PP2Ac nitration using a mimic peptide is a potential preventive strategy for Endothelial-to-mesenchymal transition in renal fibrosis
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten phosphohydrolase
that loss of glucocerebrosidase function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation
Data indicate that protein phosphatase PP2A is required for the function of T(reg (Montrer KCNH2 Protéines)) cells and the prevention of autoimmunity.
Moreover, PP2Acalpha2-overexpressed cells demonstrated increased expression of IGBP1 (Montrer IGBP1 Protéines), activated mTORC1 signaling to reduce basal autophagy and increased anchorage-independent growth. Our study provides new insights into the complex mechanisms of PP2A (Montrer PPP2R4 Protéines) regulation.
protein phosphatase 2A (PP2A (Montrer PPP2R4 Protéines))-mediated Raf (Montrer RAF1 Protéines)-MEK (Montrer MAP2K1 Protéines)-ERK (Montrer EPHB2 Protéines) signaling was involved in glutaminolysis in endothelial cells.
Studies indicate that protein phosphatase methylesterase-1 (PME-1 (Montrer PPME1 Protéines)) negatively regulates protein phosphatase 2A (PP2A (Montrer PPP2R4 Protéines)) activity by highly complex mechanisms.
Binding of PP2A (Montrer PPP2R4 Protéines) and Akt (Montrer AKT1 Protéines) increased in response to cAMP or phosphatidic acid (PA), suggesting that their binding is directly responsible for the inactivation of Akt (Montrer AKT1 Protéines) during decidualization.
Knockdown of Alpha4 preferentially impacts the expression of PP4c (Montrer PPP4C Protéines) and PP6c (Montrer PPP6C Protéines) compared to expression levels of PP2Ac.
these data support a role for the novel PP2Ac-CIN85 (Montrer SH3KBP1 Protéines) complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
PP2Ac upregulation has a poor prognostic impact on the overall survival of hepatocellular carcinoma (HCC (Montrer FAM126A Protéines)) patients and contributes to the aggressiveness of HCC (Montrer FAM126A Protéines). PP2Ac may represent a potential therapeutic target for HCC (Montrer FAM126A Protéines).
Data show that downregulating proto-oncogene (Montrer RAB1A Protéines) protein Akt (p-Akt (Montrer AKT1 Protéines)) by inhibiting PP2A (Montrer PPP2R4 Protéines) inhibitor SET-mediated protein phosphatase 2A (PP2A (Montrer PPP2R4 Protéines)) inactivation determined the pro-apoptotic effects of EMQA and paclitaxel combination treatment.
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) deficient castration resistant prostate cancer (CRPC) progression.
changes in PP2A (Montrer PPP2R2B Protéines) activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function
The findings demonstrate an endothelial VEGF (Montrer VEGFA Protéines) resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A (Montrer PPP2R2B Protéines)-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.
PP2A (Montrer PPP2R2B Protéines) and AIP1 (Montrer PDCD6IP Protéines) cooperatively induce activation of ASK1 (Montrer MAP3K5 Protéines)-JNK (Montrer MAPK8 Protéines) signaling and vascular endothelial cell apoptosis.
Hsp27 (Montrer HSPB1 Protéines) is dephosphorylated by PP2A (Montrer PPP2R2B Protéines) in dorsal ruffles, in non-caveolar lipid raft microdomains.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
, protein phosphatase 2a, catalytic subunit, alpha
, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
, protein phosphatase 2, catalytic subunit, beta isoform
, protein phosphatase 2, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like
, protein phosphatase 2a, catalytic subunit, alpha isoform
, protein phosphatase 2A catalytic subunit, alpha isoform
, replication protein C
, serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
, protein phosphatase 2, catalytic subunit, alpha isoform
, protein phosphatase-2A-alpha
, type 2A protein phosphatase catalytic subunit
, protein phosphatase 2A alpha subunit
, phosphatase 2A catalytic subunit