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Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome
We identified two novel genes, SOS2 and LZTR1, associated with Noonan syndrome, thereby expanding the molecular spectrum of RASopathies.
multicenter pharmacogenetic study in children (ages 6-11): Data suggest that SNP in SOS2 (rs13379306) in children with growth hormone deficiency is associated with drug resistance to hormone replacement therapy with recombinant human growth hormone.
intracellular Francisella tularensis novicida triggers temporal and early activation of Ras through the SOS2/GrB2/PKCalpha/PKCbetaI quaternary complex; Ras signalling by intracellular F. tularensis is essential for intracellular proliferation in the cytosol
Significant association of single nucleotide polymorphism within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease, was confirmed.
Loss of MADD expression resulted in reduced Grb2 and Sos1/2 recruitment to the TNFR1 complex and decreased Ras and MEKK1/2 activation
The increased activity of the PI3K/AKT pathway led to downregulation of the surface receptor CD62L in Sos-1/2dKO T cells and a subsequent impairment in T-cell migration.
Absolute counts of mature B and T cells in spleen and peripheral blood were unchanged in single-knockout mutants, while significantly reduced in Sos1/2 double-knockout mice.
assessed the independent and combined roles for the RasGEFs Sos1, Sos2, and RasGRP1 during thymocyte development
Vav1 transduces TCR signals to Ras by controlling recruitment of RasGRP1 to the membrane and recruitment of Sos1 and -2 to the transmembrane adapter protein LAT.
Sos2 is dispensable for both NMDA-induced Erk activation in cortical neuron cultures from neonatal mice, and for LTP induction at the Schaffer-CA1 synapses in brain slices from young mice that is known to require NMDA receptor signaling.
mRNA expression increases after chronic clozapine treatment in the prefrontal cortex\\; may play a role in synaptic function
son of sevenless homolog 2
, son of sevenless 1
, guanine nucleotide exchange factor
, guanine nucleotide releasing factor