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Human Monoclonal TCF3 Primary Antibody pour IP, WB - ABIN967393
Bain, Gruenwald, Murre: E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. dans Molecular and cellular biology 1993
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Human Polyclonal TCF3 Primary Antibody pour WB - ABIN151858
Nie, Xu, Vladimirova, Sun: Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. dans The EMBO journal 2003
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Human Monoclonal TCF3 Primary Antibody pour FACS, ELISA - ABIN1724729
Firulli, Hadzic, McDaid, Firulli: The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. dans The Journal of biological chemistry 2000
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Human Polyclonal TCF3 Primary Antibody pour IHC (p), IHC - ABIN188732
Greenbaum, Lazorchak, Zhuang: Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. dans The Journal of biological chemistry 2004
Human Monoclonal TCF3 Primary Antibody pour ELISA, WB - ABIN563112
Schmeisser, Grabrucker, Bockmann, Boeckers: Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses. dans The Journal of biological chemistry 2009
TCF3 gene silencing inhibits esophageal cancer cells growth and proliferation, suppresses cell cycle progression, and promotes apoptosis.
suggested that the upregulation of TCF3 was a critical prognostic factor for nasopharyngeal carcinoma
Based on results, TCF3 is clearly associated with the progression of cervical squamous cell carcinoma. This is the first time that it has been reported that TCF3 can act as a tumor promoter in cervical cancer and thus might be of great significance in the prognosis of CSCC (Montrer CYP11A1 Anticorps).
We conclude that inactivation of TCF3 contributes to oncogenic program of classical Hodgkin lymphoma
This is the first time the protein partners of either E2A-PBX1 (Montrer PBX1 Anticorps) or HOXA9 (Montrer HOXA9 Anticorps) oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 (Montrer HOXA9 Anticorps) might indicate a novel function for HOX (Montrer MSH2 Anticorps) proteins independent of their transcriptional activity.
Poly (ADP-ribose) polymerase (Montrer PARP1 Anticorps) inhibitors selectively induce cytotoxicity in TCF3-HLF (Montrer EPAS1 Anticorps)-positive leukemic cells.
MiR (Montrer MLXIP Anticorps)-138 may be a tumor suppressor and potential prognostic biomarker in cervical cancer. Its downstream target, TCF3, may also regulate cancer development in a reverse manner as miR (Montrer MLXIP Anticorps)-138.
High levels of TCF3 in gliomas promote glioma development through the Akt (Montrer AKT1 Anticorps) and Erk (Montrer EPHB2 Anticorps) pathways.
TWIST1 (Montrer TWIST1 Anticorps)-E12 (Montrer ELSPBP1 Anticorps) protein heterodimeric complexes may thus constitute the main active forms of TWIST1 (Montrer TWIST1 Anticorps) with regard to senescence inhibition over the time course of breast tumorigenesis.
Review of the role of the E2A-PBX1 (Montrer PBX1 Anticorps) gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B (Montrer SPIB Anticorps) and the suppressor of cytokine signaling 3 (SOCS3 (Montrer SOCS3 Anticorps)), which both downregulated Foxp3 (Montrer FOXP3 Anticorps) expression. These findings demonstrate that the balance of Id3 (Montrer ID3 Anticorps) and E47 controls the maintenance of Foxp3 (Montrer FOXP3 Anticorps) expression in Treg cells and, thus, contributes to Treg cell plasticity.
this study identifies E2A target genes in embryonic neural stem cells and demonstrates that E47 regulates neuronal differentiation via p57(KIP2 (Montrer CDKN1C Anticorps)).
If Gfi1 (Montrer ZNF163 Anticorps) levels fall below a threshold, Id1 (Montrer ID1 Anticorps) expression increases and renders E2A unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
these data identified E2A and E2-2 (Montrer TCF4 Anticorps) as central regulators of B cell immunity.
down-regulation of Id3 (Montrer ID3 Anticorps) in B cells is essential for releasing E2A and E2-2 (Montrer TCF4 Anticorps), which in a redundant manner are required for antigen-induced B cell differentiation.
Data suggest a novel mechanism of drug resistance in which E2a and PRC2 drive changes in the B-cell epigenome; these alterations attenuate alkylating agent treatment-induced apoptosis.
These findings suggest that miR (Montrer MLXIP Anticorps)-506-3p played an important role in regulating NSC proliferation and differentiation via targeting TCF3 (Montrer TCF7L1 Anticorps), and provide a promising avenue for future in-depth research into the functions of miR (Montrer MLXIP Anticorps)-506-3p and TCF3 (Montrer TCF7L1 Anticorps) in nervous system development.
Conditional expression of E2A-HLF (Montrer HLF Anticorps) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (Montrer CDH1 Anticorps) expression led to epithelial-mesenchymal transition in human hepatocytes.
Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.
Data indicte that Tcf-1 (Montrer HNF1A Anticorps) and Lef-1 (Montrer LEF1 Anticorps) exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
VDR interacting repressor
, class B basic helix-loop-helix protein 21
, helix-loop-helix protein HE47
, immunoglobulin transcription factor 1
, kappa-E2-binding factor
, negative vitamin D response element-binding protein
, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
, transcription factor E2-alpha
, transcription factor ITF-1
, vitamin D receptor-interacting repressor
, transcription factor 3
, immunoglobulin enhancer-binding factor E12/E47
, transcription factor A1
, transcription factor E2a
, pancreas specific transcription factor 1c
, transcription regulator Pan
, transcription factor XE12/XE47
, class A basic helix-loop-helix transcription factor G12
, helix-loop-helix protein E12
, helix-loop-helix protein E47
, transcription factor 7-like 1 (T-cell specific, HMG-box)