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We conclude that inactivation of TCF3 contributes to oncogenic program of classical Hodgkin lymphoma
This is the first time the protein partners of either E2A-PBX1 (Montrer PBX1 Protéines) or HOXA9 (Montrer HOXA9 Protéines) oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 (Montrer HOXA9 Protéines) might indicate a novel function for HOX (Montrer MSH2 Protéines) proteins independent of their transcriptional activity.
Poly (ADP-ribose) polymerase (Montrer PARP1 Protéines) inhibitors selectively induce cytotoxicity in TCF3-HLF (Montrer EPAS1 Protéines)-positive leukemic cells.
MiR (Montrer MLXIP Protéines)-138 may be a tumor suppressor and potential prognostic biomarker in cervical cancer. Its downstream target, TCF3, may also regulate cancer development in a reverse manner as miR (Montrer MLXIP Protéines)-138.
High levels of TCF3 in gliomas promote glioma development through the Akt (Montrer AKT1 Protéines) and Erk (Montrer EPHB2 Protéines) pathways.
TWIST1 (Montrer TWIST1 Protéines)-E12 (Montrer ELSPBP1 Protéines) protein heterodimeric complexes may thus constitute the main active forms of TWIST1 (Montrer TWIST1 Protéines) with regard to senescence inhibition over the time course of breast tumorigenesis.
Review of the role of the E2A-PBX1 (Montrer PBX1 Protéines) gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
Our data suggest that E2A antagonism of PU.1 activity contributes to its ability to commit multipotential hematopoietic progenitors to the lymphoid lineages.
E47 is a novel substrate of PAK5 (Montrer PAK6 Protéines), and PAK5 (Montrer PAK6 Protéines)-mediated phosphorylation of E47 promotes epithelial-mesenchymal transition. High expression of phospho-E47 was associated with an aggressive phenotype of colon cancer and metastasis.
We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3-PBX1 (Montrer PBX1 Protéines) as well as an enrichment of genes involved in immunity and infection pathways in ETV6 (Montrer ETV6 Protéines)-RUNX1 (Montrer RUNX1 Protéines) subtype
Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B (Montrer SPIB Protéines) and the suppressor of cytokine signaling 3 (SOCS3 (Montrer SOCS3 Protéines)), which both downregulated Foxp3 (Montrer FOXP3 Protéines) expression. These findings demonstrate that the balance of Id3 (Montrer ID3 Protéines) and E47 controls the maintenance of Foxp3 (Montrer FOXP3 Protéines) expression in Treg cells and, thus, contributes to Treg cell plasticity.
this study identifies E2A target genes in embryonic neural stem cells and demonstrates that E47 regulates neuronal differentiation via p57(KIP2 (Montrer CDKN1C Protéines)).
If Gfi1 (Montrer ZNF163 Protéines) levels fall below a threshold, Id1 (Montrer ID1 Protéines) expression increases and renders E2A unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
these data identified E2A and E2-2 (Montrer TCF4 Protéines) as central regulators of B cell immunity.
down-regulation of Id3 (Montrer ID3 Protéines) in B cells is essential for releasing E2A and E2-2 (Montrer TCF4 Protéines), which in a redundant manner are required for antigen-induced B cell differentiation.
Data suggest a novel mechanism of drug resistance in which E2a and PRC2 drive changes in the B-cell epigenome; these alterations attenuate alkylating agent treatment-induced apoptosis.
These findings suggest that miR (Montrer MLXIP Protéines)-506-3p played an important role in regulating NSC proliferation and differentiation via targeting TCF3 (Montrer TCF7L1 Protéines), and provide a promising avenue for future in-depth research into the functions of miR (Montrer MLXIP Protéines)-506-3p and TCF3 (Montrer TCF7L1 Protéines) in nervous system development.
Conditional expression of E2A-HLF (Montrer HLF Protéines) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (Montrer CDH1 Protéines) expression led to epithelial-mesenchymal transition in human hepatocytes.
Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.
Data indicte that Tcf-1 (Montrer HNF1A Protéines) and Lef-1 (Montrer LEF1 Protéines) exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
VDR interacting repressor
, class B basic helix-loop-helix protein 21
, helix-loop-helix protein HE47
, immunoglobulin transcription factor 1
, kappa-E2-binding factor
, negative vitamin D response element-binding protein
, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
, transcription factor E2-alpha
, transcription factor ITF-1
, vitamin D receptor-interacting repressor
, transcription factor 3
, immunoglobulin enhancer-binding factor E12/E47
, transcription factor A1
, transcription factor E2a
, pancreas specific transcription factor 1c
, transcription regulator Pan
, transcription factor XE12/XE47
, class A basic helix-loop-helix transcription factor G12
, helix-loop-helix protein E12
, helix-loop-helix protein E47
, transcription factor 7-like 1 (T-cell specific, HMG-box)