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MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K (Montrer PIK3CA Protéines)/Akt (Montrer AKT1 Protéines)/mTOR (Montrer FRAP1 Protéines) signaling pathway in prostate cancer cells.
MED15 as a potential biomarker for head and neck squamous cell carcinoma
MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors
MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression.
these findings implicate MED15 in CRPC, and as MED15 is evolutionary conserved, it is likely to emerge as a lethal phenotype in other therapeutic-resistant diseases, and not restricted to our disease model.
MED15 and PUM1 (Montrer PUM1 Protéines) proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 (Montrer ATXN1 Protéines) protein misfolding and proteotoxicity in vitro and in vivo.
The data identify PC2 (Montrer KRT6B Protéines) as a novel PLAGL2 (Montrer PLAGL2 Protéines)-binding protein and important mediator of PLAGL2 (Montrer PLAGL2 Protéines) transactivation.
Methylation of TIG1 (Montrer RARRES1 Protéines) in prostatic neoplasms correlates with methylation of the retinoic acid receptor beta (Montrer RARB Protéines) gene.
Limited role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia.
TIG1 (Montrer RARRES1 Protéines) gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, mediator complex subunit 15
, PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
, mediator of RNA polymerase II transcription subunit 15
, CTG repeat protein 7a
, PC2 glutamine/Q-rich-associated protein
, PC2-glutamine-rich-associated protein
, TPA inducible gene-1
, TPA inducible protein
, TPA-inducible gene 1 protein
, activator-recruited cofactor 105 kDa component
, activator-recruited cofactor, 105-kD
, positive cofactor 2 glutamine/Q-rich-associated protein
, positive cofactor 2, glutamine/Q-rich-associated protein
, trinucleotide repeat containing 7
, trinucleotide repeat-containing gene 7 protein
, positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein