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MED15 does seem to play a tumour promoting role in the progression and metastatic spread of renal cell carcinoma
MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells.
MED15 as a potential biomarker for head and neck squamous cell carcinoma
MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors
MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression.
these findings implicate MED15 in CRPC, and as MED15 is evolutionary conserved, it is likely to emerge as a lethal phenotype in other therapeutic-resistant diseases, and not restricted to our disease model.
MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo.
The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation.
Methylation of TIG1 in prostatic neoplasms correlates with methylation of the retinoic acid receptor beta gene.
Limited role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia.
TIG1 gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma
SREBPs use the evolutionarily conserved ARC105 (also called MED15) subunit to activate target genes
results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling
The protein encoded by this gene was identified as ARC105, a 105kDa component of the Activator-Recruited Cofactor (ARC) that is involved in mediating gene activation by several classes of transcriptional regulators.
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, mediator complex subunit 15
, PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
, mediator of RNA polymerase II transcription subunit 15
, CTG repeat protein 7a
, PC2 glutamine/Q-rich-associated protein
, PC2-glutamine-rich-associated protein
, TPA inducible gene-1
, TPA inducible protein
, TPA-inducible gene 1 protein
, activator-recruited cofactor 105 kDa component
, activator-recruited cofactor, 105-kD
, positive cofactor 2 glutamine/Q-rich-associated protein
, positive cofactor 2, glutamine/Q-rich-associated protein
, trinucleotide repeat containing 7
, trinucleotide repeat-containing gene 7 protein
, positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein