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Body weight mostly and to a smaller extent genetic polymorphisms of UGT2B7 can influence varenicline exposure. Dose adjustment based on body weight and, if available, on UGT2B7 genotype might be useful to improve clinical efficacy and tolerability of varenicline.
UGT2B7 rs7662029 was associated with log (C0/D) using a dominant (p = 0.041) and an additive (p = 0.038) model, ABCC2 rs717620 was associated with log (C0/D) using a recessive model (p = 0.019).
UGT2B7 polymorphisms may play a crucial role in the occurrence and development of breast cancer in the Han Chinese population
UGT2B7 could localize to the ER without any retention signal.
UGT2B7 rs7439366 increased the colorectal cancer risk in dominant model (OR=0.76, 95% CI=0.61-0.95, P=0.02). However, as for the rs7435335 and rs12233719, we did not find their associations with cancer risk in all genetic models. In addition, the rs7441774 was found to be associated with breast cancer risk and significantly reduced papillary thyroid cancer risk
combination of the T/C and C/C genotypes of the polymorphism rs11706052 (IMPDH2) was associated with a 4.2-fold protection, and the combination of the genotypes A/G and G/G of the polymorphism rs7438135 (UGT2B7) showed a 2.4-fold protection, against rejection
This study aimed to explore the connection between the 10-hydroxycarbazepine concentration and genes such as ATP-binding cassette B1 (ABCB1), ATP-binding cassette C2 (ABCC2), UDP-glucuronosyltransferase-2B7 and sodium voltage-gated channel alpha subunit 2 (SCN2A), which participate in the antiepileptic function of oxcarbazepine
The palliative effect of oxycontin is better in patients with UGT2B7 802CC than in those with 802TT.
The genotypes of UGT1A4 142T>G, UGT2B7 -161C>T, and UGT2B7 372A>G were identified by polymerase chain reaction analyses.
A UGT2B7 -161 T allele serves as a potential biomarker for predicting a low occurrence of cardiotoxicity in breast cancer patients undergoing epirubicin/cyclophosphamide-docetaxel adjuvant chemotherapy.
Genetic polymorphism in UGT1A4 and UGT2B7 may play a modest role in lamotrigine clearance changes during pregnancy. In addition, study indicates that the sex of the foetus influenced significantly the change in LTG clearance.
Meanwhile, only mitragynine and zerumbone inhibited ZDV(probe substrate to determine UGT2B7 activity) glucuronidation in RLM with IC50 values of 51.20 +/- 5.95 muM and 8.14 +/- 2.12 microM, respectively, indicating a difference between the human and rat microsomal model so caution must be exercised when extrapolating inhibitory metabolic data from rats to humans.
Clopidogrel carboxylic acid is metabolized mainly by UGT2B7 and UGT2B4 in the liver and by UGT2B17 in the small intestinal wall.
rs7668282 (UGT2B7, T>C) was more prevalent in sodium valproate (VPA)-resistant patients than drug-responsive patients. rs2242480 (CYP3A4, C>T) and rs10188577 (SCN1A, T>C) were more prevalent in drug-responsive patients compared to drug-resistant patients. In children with generalized seizures on VPA therapy, polymorphisms of UGT2B7, CYP3A4, and SCN1A genes were associated with seizure reduction.
Review/Meta-analysis: UGT2B7 G211T and C161T polymorphisms were able to affect the pharmacokinetics in epilepsy patients treated with valproic acid
Icaritin was subjected to significant glucuronidation, wherein UGT1A3, 1A7, 1A8, 1A9 and 2B7 were main contributing enzymes.
This study is the first attempt to investigate the association of genetic polymorphisms of UGT2B7 with anti-tuberculosis drug-induced liver injury (ATLI) in Chinese Han. There is no significant association between UGT2B7 polymorphisms and ATLI in Chinese Han.
This study analyzed the genotypes of 195 epilepsy patients, and preliminarily results confirmed the distribution of UGT2B7 *2 genotypes (802 C > T, H268 > Y) in a population of epilepsy patients. Results indicated that polymorphisms in the UGT2B7 *2 gene exert specific effects on the blood concentrations of valproic acid, but not carbamazepine.
In summary, we explored the effects of CYP3A5*3, UGT2B7*2, and UGT2B7*3 variants on steady-state carbamazepine (CBZ) concentrations in 62 epileptic patients. Our study found that the UGT2B7*2 variant, but not the CYP3A5*3 and UGT2B7*3 variants, can affect steady-state CBZ concentrations in these patients.
Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
UDP glycosyltransferase 2 family, polypeptide B28
, UDP glucuronosyltransferase 2 family, polypeptide B7
, UDP-glucuronosyltransferase 2B7
, UDP-glucuronosyltransferase 2B7-like
, 3,4-catechol estrogen specific
, 3,4-catechol estrogen-specific UDPGT
, UDP glucuronosyltransferase 2B7
, UDP-glucuronosyltransferase 2B9
, UDP-glucuronyltransferase, family 2, beta-7
, UDPGT 2B7
, UDP-glucuronosyltransferase 2B8
, UDPGT 2B8