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Data indicate the cell type-specific and mechanistic basis of the association between the rs9277534-G/A single nucleotide polymorphisms (SNP) and HLA-DPB1 expression.
The three alleles HLA-B58:01, HLA-DPB110:01 and HLA-DRB111:01 may protect against HIV-2 disease progression towards AIDS.
These results suggest the involvement of class II molecules HLA-DPA1 and HLA-DPB1 in hepatitis B virus reactivation after treatment with immunomodulatory agents.
HLA-DPB1 gene polymorphisms HLA-DPB103:01, DPB104:02, DPB113:01, rs9277535, and rs3117027) are significantly associated with cervical cancer
Independent association of HLA-DPB1*02:01 with rheumatoid arthritis
Evolutionary analysis revealed that rs9277534 represented a highly conserved HLA-DPB1 Ex3-3'UTR region and may provoke acute graft-versus-host disease differently to T-cell epitope mismatching algorithm, reflecting exon 2 polymorphisms.
Data suggest that HLA-DP molecules with beta-chains encoding Gly84 (DP(84Gly)) uses both class I and II antigen-processing pathways to present peptides derived from intracellular and extracellular sources.
HLA-DP polymorphisms (rs3077 and rs9277535) were associated with Systemic lupus erythematosus susceptibility in a Chinese population
High frequency expression of DPB1*0401 and *0601 are significantly associated with susceptibility to rheumatoid arthritis, it may be a risk factor for occurrence of rheumatoid arthritis. Low frequency expression of DPB1*0101, *0402 and *0501 may be negatively associated with rheumatoid arthritis, it may be a protective factor for occurrence of rheumatoid arthritis.
The rs3117242 of HLA-DPB1 could be considered a genetic risk factor for granulomatosis with polyangiitis in Chinese Han people.
HLA-DPB1*05:01 gene was associated with the geographical region of PV and the BTNL2 gene was significantly associated with family history and age of onset of PV. In conclusion, the HLA-DPB1*05:01 and BTNL2 genes might be responsible for the complicacy of clinical features.
In this single-center study, HLA-DPB1 matching influenced outcomes of patients undergoing ASCT for hematologic malignancy.
HLA-DPB1*15:01 allele was more frequent in the spontaneous seroconverted control group compared to Chronic hepatitis B Turkish patients.
Genotyping and expression analysis in HLA class II gene revealed that two single nucleotide polymorphisms of HLA-DPB1 (rs2071025 and rs3116996) were significantly correlated to RNA expression and progression of hepatitis C virus-related liver diseases.
Amino acid changes in the allergen-binding pocket of HLA-DPbeta1 are likely to influence pollinosis/sensitization to the allergenic peptide of JC pollen and determine the pollinosis risk for each individual exposed to JC pollen.
The results showed that rs9277535 HLA-DPB1 allele frequency is associated with chronic hepatitis B infection in the Turkish patients.
report contributes to emerging data showing clinical significance of the HLA-DP region genetic markers beyond structural matching of DPB1 alleles.
The HLA-DP rs9277535 variant genotypes were directly associated with hepatitis B virus persistence compared to healthy controls.
No statistically significant association was found between rs9277535 SNP and chronic hepatitis B.
HLA-DPA1 and HLA-DPB1 variants can determine susceptibility or protective effect against Hepatitis B virus infection in an Indonesian population.
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
major histocompatibility complex, class II, DP beta 1
, B-L beta minor
, BLB major
, Bl-Beta II protein
, MHC class II B-L beta chain
, MHC class II antigen beta chain
, MHC class II beta 1 domain
, MHC class II beta chain 1
, MHC class II beta chain 2
, major histocompatibility complex class II B
, HLA DP14-beta chain
, HLA class II histocompatibility antigen, DP beta 1 chain
, HLA class II histocompatibility antigen, DP(W4) beta chain
, HLA-DP histocompatibility type, beta-1 subunit
, MHC HLA DPB1
, MHC class II HLA-DP-beta-1
, MHC class II HLA-DRB1
, MHC class II antigen DP beta 1 chain
, MHC class II antigen DPB1
, MHC class II antigen DPbeta1
, beta1 domain MHC class II HLA DPB
, class II HLA beta chain
, major histocompatibility complex class II antigen beta chain