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This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.
Alternative names and synonyms associated with Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2)
- major histocompatibility complex, class II, DQ alpha 2 (HLA-DQA2) anticorps
- DX-ALPHA anticorps
- HLA-DXA anticorps
Protein level used designations for HLA-DQA2
DX alpha chain , HLA class II histocompatibility antigen, DQ alpha 2 chain , HLA class II histocompatibility antigen, DQ(6) alpha chain , MHC class II DQA2