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Human Polyclonal DNM2 Primary Antibody pour WB - ABIN152770
McNiven: Dynamin: a molecular motor with pinchase action. dans Cell 1998
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Human Monoclonal DNM2 Primary Antibody pour IHC, ELISA - ABIN966018
Quan, Robinson: Rapid purification of native dynamin I and colorimetric GTPase assay. dans Methods in enzymology 2006
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Human Monoclonal DNM2 Primary Antibody pour IHC (fro), IHC (p) - ABIN3073353
Yoo, Jeong, Kwon, Hur, Park, Han: Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells. dans The Journal of biological chemistry 2002
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DNM2 is a substrate for CDK1 (Montrer CDK1 Anticorps)-dependent phosphorylation, which plays an important role in the regulation of human sperm acrosomal exocytosis.
Data found DNM2 highly expressed compared in both forms of ALL and associated with poor prognosis and with tumor cell proliferation. Also, Ikaros (Montrer IKZF1 Anticorps) directly binds the DNM2 promoter and suppresses its expression.
Inhibition of cortactin (Montrer CTTN Anticorps) or dynamin-2 abrogated the increased virus entry observed in DBN1 (Montrer DBN1 Anticorps)-deficient cells, suggesting that DBN1 (Montrer DBN1 Anticorps) suppresses dynamin (Montrer DNM1 Anticorps)-mediated endocytosis via interaction with cortactin (Montrer CTTN Anticorps).
a new AHI-1 (Montrer AHI1 Anticorps)-BCR-ABL (Montrer ABL1 Anticorps)-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS (Montrer ROS1 Anticorps)-mediated autophagy. Thus, targeting this complex may facilitate eradication of LSCs for curative therapies
dynamin-2, as a tetramer, might help to establish hemi-fusion and stabilizes the pore during HIV-1 fusion.
Data suggest DNM2/RRAGB (Montrer RRAGB Anticorps)- (or DNM2/RRAGC (Montrer RRAGC Anticorps)-)dependent endocytosis of extracellular amino acids (AAs (Montrer FGD1 Anticorps)) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB (Montrer RHEB Anticorps) = Ras homolog enriched in brain (Montrer RHEB Anticorps); DNM2 = dynamin II; RRAG = Ras-related GTP binding protein (Montrer RAB10 Anticorps))
Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.
Data demonstrate that dynamin II is required for the E2:ERalpha (Montrer ESR1 Anticorps) signaling of physiological functions and uncovers a role for autophagy in the control of ERalpha (Montrer ESR1 Anticorps) turnover.
This study reported the clinical characteristics, molecular diagnosis strategy, and DNM2 gene mutations of four Chinese Han patients with centronuclear myopathy.
uncover a link between the dynamin 2 function and JNK (Montrer MAPK8 Anticorps) signaling which leads to AP-1 (Montrer FOSB Anticorps) induction
The authors demonstrate that ablation of DNM2 in early spermatogenesis results in germ cell arrest during prophase I of meiosis, subsequent loss of all post-meiotic germ cells and concomitant sterility. These effects become exacerbated with age, and ultimately result in the demise of the spermatogonial stem cells and a Sertoli cell only phenotype.
Loss of Dynamin 2 GTPase (Montrer RACGAP1 Anticorps) function results in microcytic anaemia.
DNM2 mutations cooperate with Lmo2 (Montrer LMO2 Anticorps) T-cell oncogenes by enhancing IL-7 (Montrer IL7 Anticorps) signalling.
Genetic disruption of Dyn2 GTPase (Montrer RACGAP1 Anticorps) activity selectively in hepatic stellate cells enhances fibrogenesis.
Oxidative stress-induced (Montrer SQSTM1 Anticorps) apoptosis and reactive oxygen species production are attenuated by not only Drp1 (Montrer CRMP1 Anticorps) inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes.
Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.
Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis
Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes
DNM2-dependent endocytosis in megakaryocytes regulates megakaryopoiesis, thrombopoiesis, and bone marrow homeostasis.
Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.
role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase (Montrer NOS3 Anticorps) activity.
Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.
LKT-mediated cell death involve dynamin-2 and cyclophilin D
DNM2-S619L causes disease, in part, by interfering with membrane tubulation
Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.
Upregulation of miR (Montrer MYLIP Anticorps)-124 expression corresponded to decreased expression of its target, DNM2, in the Japanese encephalitis virus -infected PK15 cells.
Dynamin 2 possibly regulates porcine oocyte maturation through its effects on actin-mediated spindle positioning and cytokinesis, and that this may depend on regulating ARP2 (Montrer ACTR2 Anticorps) localization.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
, dynamin 2
, dynamin II