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TRIM71 acts through post-transcriptional repression of Lin28B and subsequent modulation of let-7-HMGA2 signaling during tumorigenesis to potentially function as a tumor suppressor.
Studies indicate most-studied TRIpartite Motif (TRIM (Montrer TRAT1 Protéines))-NHL proteins TRIM2 (Montrer TRIM2 Protéines), TRIM3 (Montrer TRIM3 Protéines), TRIM32 (Montrer TRIM32 Protéines) and TRIM71, and their mutations have been linked to diseases.
Consistent with the let-7 microRNA stimulatory role of TRIM71 via Lin28B (Montrer LIN28B Protéines) polyubiquitination.
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing.
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation
Repression of human TRIM71 and the zebrafish lin-41 ortholog was abolished when predicted let-7 target sites were mutated. Regulation of TRIM71 expression by let-7 seems to have been evolutionarily conserved.
LIN41 interacts with p53 (Montrer TP53 Protéines), controls its abundance by ubiquitination and antagonizes p53 (Montrer TP53 Protéines)-dependent pro-apoptotic and pro-differentiation responses. In vivo, lack of LIN41 is associated with upregulation of Grhl3 (Montrer GRHL3 Protéines) and widespread caspase-3 (Montrer CASP3 Protéines) activation, 2 downstream effectors of p53 (Montrer TP53 Protéines) with essential roles in neural tube closure.
suggest that Trim71 keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells
Two well-known E3 ubiquitin ligases, Trim25 (Montrer TRIM25 Protéines) (also called Efp (Montrer TRIM25 Protéines)) and Trim71 (also called Lin41), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 (Montrer EIF2C2 Protéines) stability, but through FGF signaling.
Lin-41 is genetically and biochemically downstream of both the Shh (Montrer SHH Protéines) and Fgf signaling pathways and is expressed in three phases over developmental time and most notably is associated with the developing autopod.
lin-41 is temporally regulated by miRNAs in order to direct key developmental events such as limb formation.
May be involved in controlling the timing of organ formation during development (By similarity).
E3 ubiquitin-protein ligase TRIM71
, abnormal cell LINeage LIN-41
, homolog of C. elegans Lin-41
, protein lin-41 homolog
, tripartite motif-containing 71
, tripartite motif-containing protein 71
, B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41)
, Drosophila dappled/ vertebrate TRipartite Motif protein related
, lin-41 homolog