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STAT3 anticorps (pTyr705)

Name: STAT3 anticorps (pTyr705)
SKU: ABIN968833
Availability: InStock

Cet anticorps Souris Monoclonal détecte spécifiquement STAT3 dans WB et ICS. Il présente une réactivité avec des échantillons de Humain et Souris. Il a été cité dans 3+ publications.

Western blot analysis for Stat3 (pY705). (STAT3 anticorps (pTyr705))

1 image

(3 références)

N° du produit ABIN968833

214,31 €

Plus frais de livraison 40,00 € et TVA

50 μg

Destination: France

Envoi sous 12 à 15 jours ouvrables

Aperçu rapide pour STAT3 anticorps (pTyr705) (ABIN968833)

Antigène

Voir toutes STAT3 Anticorps

STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Reactivité

Humain, Souris

Hôte

Souris

Clonalité

Monoclonal

Conjugué

Cet anticorp STAT3 est non-conjugé

Application

Western Blotting (WB), Intracellular Staining (ICS)

Clone

4-P

Discover our top product STAT3 Anticorps primaire

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pTyr705

Réactivité croisée

Souris

Attributs du produit

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène

Phosphorylated Human Stat3 Peptide

Isotype

IgG2a kappa
anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (C-Term) antibody
KO Validated STAT3 Reactivité: Humain WB, IF, ICC, IHC (p) Hôte: Lapin Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 640-770) antibody
STAT3 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pTyr705) antibody
STAT3 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IP, IF, ICC Hôte: Lapin Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody
STAT3 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IP, IF, ICC Hôte: Lapin Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (C-Term) antibody
STAT3 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody
STAT3 Reactivité: Humain, Souris, Rat WB, IHC (p), FACS, IF (cc) Hôte: Lapin Monoclonal 4G1 unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 670-769) antibody
STAT3 Reactivité: Humain WB, ELISA, IF, PLA Hôte: Souris Monoclonal 4D6 unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (C-Term) antibody
Verified STAT3 Reactivité: Humain, Souris IHC, ELISA, IF, FACS Hôte: Chèvre Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 233-330) antibody
STAT3 Reactivité: Humain, Souris, Rat, Lapin WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pTyr705) antibody
STAT3 Reactivité: Humain, Souris, Rat, Porc, Lapin, Poulet WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated

Commentaires

Related Products: ABIN968533, ABIN968534, ABIN967389, ABIN967808

Restrictions

For Research Use only
Format

Liquid

Concentration

250 μg/mL

Buffer

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

-20 °C

Stockage commentaire

Store undiluted at -20° C.
Kanai, Konda, Nakajima, Izumi, Kanda, Nanakin, Kubohara, Chiba: "Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway." dans: Oncogene, Vol. 22, Issue 4, pp. 548-54, (2003) (PubMed).

Smith, Crompton: "Expression of v-src in mammary epithelial cells induces transcription via STAT3." dans: The Biochemical journal, Vol. 331 ( Pt 2), pp. 381-5, (1998) (PubMed).

Fu, Zhang: "Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter." dans: Cell, Vol. 74, Issue 6, pp. 1135-45, (1993) (PubMed).
Antigène

STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Autre désignation

Stat3

Sujet

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat3 is a 92-kDa protein that is activated as a DNA- binding protein through cytokines, such as IL-6, and growth factors, such as EGF. Stat3 activation occurs via tyrosine phosphorylation at Y705. Tyrosine phosphorylation in response to cytokine stimulation is generally mediated by JAK1. Upon activation, Stat3 dimerizes, translocates to the nucleus and binds DNA response elements, thereby regulating gene expression. It has been reported that Stat3 binds to DNA as a homodimer, but it is also capable of binding as a heterodimer with Stat1. In addition to tyrosine phosphorylation, Stat3 is also phosphorylated at S727 via the MAPK pathway. Stat3 is widely expressed and can bind to the sis-inducible element (SIE) site from the c-fos promoter. This site is similar to the GAS element that is present in IFN-gamma induced genes. Thus, phosphorylation of Y705 in Stat3 occurs in response to growth factors and cytokines, and is essential for normal transcription activity.
The 4/P-STAT3 monoclonal antibody recognizes the phosphorylated Y705 of Stat3.

Poids moléculaire

92 kDa

Pathways

Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor