anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Anticorps

MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. De plus, nous expédions MAPK8IP1 Protéines (4) et MAPK8IP1 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MAPK8IP1 19099 Q9WVI9
MAPK8IP1 116457 Q9R237
MAPK8IP1 9479 Q9UQF2
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Top anti-MAPK8IP1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 73 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué FACS, IF, IHC (p), WB Western blot analysis of JIP1 Antibody (C-term) (ABIN652961) in MCF-7 cell line lysates (35 µg/lane). JIP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with JIP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué IF, ELISA, WB Western blot analysis of extracts from COLO205 cells treated with Serum 20% 15', using JIP1 (Phospho-Thr103) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using JIP1 (Phospho-Thr103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué IF, IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, treated with Serum 20% 15', using JIP1 (Ab-103) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JIP1 (Ab-103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Souris Souris Inconjugué FM, WB Western blot analysis of JIP-1 on a mouse cerebellum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti- JIP-1 antibody. 50 μg Connectez-vous pour afficher 2 to 4 Days
146,73 €
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, WB 100 μL Connectez-vous pour afficher 13 Days
154,33 €
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using JIP-1 Polyclonal Antibody. 100 μL Connectez-vous pour afficher 13 Days
154,33 €
Détails
Humain Lapin Inconjugué WB Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1) mouse intestine (Lane 2) and rat kidney (Lane 3) tissue lysates. 100 μg Connectez-vous pour afficher 6 to 8 Days
337,56 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-MAPK8IP1 Polyclonal Antibody, Unconjugated (ABIN716441) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 9 to 12 Days
304,36 €
Détails
Humain Lapin Inconjugué IHC (p), WB WB Image Sample(30 ug whole cell lysate) A:Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image JIP1 antibody detects JIP1 protein at cytoplasm on mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. JIP1 antibody , diluted at 1:500. 100 μL Connectez-vous pour afficher 5 to 7 Days
357,24 €
Détails
Humain Lapin Alexa Fluor 594 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails

MAPK8IP1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-MAPK8IP1 Anticorps mieux référencés

  1. Mouse (Murine) Monoclonal MAPK8IP1 Primary Antibody pour FM, WB - ABIN968696 : Bonny, Nicod, Waeber: IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. dans The Journal of biological chemistry 1998 (PubMed)
    Show all 3 references for 968696

  2. Human Polyclonal MAPK8IP1 Primary Antibody pour FACS, IF - ABIN652961 : Mooser, Maillard, Bonny, Steinmann, Shaw, Yarnall, Burns, Schorderet, Nicod, Waeber: Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. dans Genomics 1999 (PubMed)

Plus d’anticorps contre MAPK8IP1 partenaires d’interaction

Mouse (Murine) Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (Montrer MAPK8 Anticorps) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.

  2. Enhanced fast-velocity and efficient high-frequency APP (Montrer APP Anticorps) anterograde transport observed in neurons are mediated by novel roles of JIP1b.

  3. a simple yet modular mechanism for JIP1 scaffold assembly in mammals

  4. There is a collaborative relationship between JIP1 and AKT (Montrer AKT1 Anticorps) that is required for axon growth and can be regulated by changes in neuronal activity.

  5. identify plenty of SH3 (POSH (Montrer SH3RF1 Anticorps)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (Montrer MAPK8 Anticorps) activation in CD8 (Montrer CD8A Anticorps)(+) T cells.

  6. The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (Montrer APP Anticorps) transport in neurons.

  7. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (Montrer MAP3K11 Anticorps) interaction with JIP1 scaffold protein (Montrer HOMER1 Anticorps) in cytokine-induced pancreatic beta cell death

  8. JIP1 forms a trimetric complex with RBP-Jk (Montrer RBPJ Anticorps) and Notch1 (Montrer NOTCH1 Anticorps)-IC, prevents physical association between Notch1 (Montrer NOTCH1 Anticorps)-IC and RBP-Jk (Montrer RBPJ Anticorps), sequesters RBP-JK (Montrer RBPJ Anticorps) in the cytoplasm, and suppresses the Notch1 (Montrer NOTCH1 Anticorps) signaling pathway.

  9. Data suggest that JIP1-mediated JNK (Montrer MAPK8 Anticorps) activation plays a critical role in metabolic stress regulation of the JNK (Montrer MAPK8 Anticorps) signaling pathway.

  10. JIP1b can directly modulate APP (Montrer APP Anticorps) metabolism by interacting with the APP (Montrer APP Anticorps) cytoplasmic domain, independent of its regulation of the JNK (Montrer MAPK8 Anticorps) signaling cascade.

Human Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. All binary complexes (KLC1 (Montrer KLC1 Anticorps):APP (Montrer APP Anticorps), KLC1 (Montrer KLC1 Anticorps):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (Montrer KLC1 Anticorps) and JIP1 may take part in APP (Montrer APP Anticorps) transport in Alzheimer's disease patients.

  2. analysis of the role of JIP1 in APP (Montrer APP Anticorps) transport; knockdown of JIP1 did not affect either amyloid precursor protein (Montrer APP Anticorps) transport or amyloid-beta peptide production

  3. Data show that small GTPase (Montrer RACGAP1 Anticorps) RALA (Montrer rala Anticorps) regulates formation of a JIP1 (C-Jun (Montrer JUN Anticorps)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (Montrer MAPK8 Anticorps) signaling toward FOXO4 (Montrer FOXO4 Anticorps) (forkhead box O (Montrer FOXO Anticorps) transcription factor) in response to reactive oxygen species (ROS (Montrer ROS1 Anticorps)).

  4. In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.

  5. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (Montrer MAP3K11 Anticorps) interaction with JIP1 scaffold protein (Montrer HOMER1 Anticorps) in cytokine-induced pancreatic beta cell death

  6. Data suggest that caspase 3 (Montrer CASP3 Anticorps)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (Montrer MAPK8 Anticorps) signalling during apoptotic cell death.

  7. Data show that mechanical stress of urothelial cells activates in vivo JNK (Montrer MAPK8 Anticorps), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (Montrer GJB2 Anticorps) may be directly regulated by the AP-1 (Montrer FOSB Anticorps) complex.

  8. results suggest that JIP (Montrer SMAD4 Anticorps)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (Montrer APP Anticorps), and that the JNK (Montrer MAPK8 Anticorps) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (Montrer SMAD4 Anticorps)-1b scaffold

  9. JIP1 may act as an Akt1 (Montrer AKT1 Anticorps) scaffold, which regulates the enzymatic activity of Akt1 (Montrer AKT1 Anticorps) and can exert signaling effects independent of JNK (Montrer MAPK8 Anticorps) activity

  10. JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing

MAPK8IP1 profil antigène

Profil protéine

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Gene names and symbols associated with MAPK8IP1

  • mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) anticorps
  • mitogen-activated protein kinase 8 interacting protein 1 (LOC100344706) anticorps
  • mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1) anticorps
  • IB1 anticorps
  • Jip-1 anticorps
  • JIP1 anticorps
  • Mapk8ip anticorps
  • mjip-2a anticorps
  • PRKM8IP anticorps
  • Skip anticorps

Protein level used designations for MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1 , c-Jun-amino-terminal kinase-interacting protein 1-like , C-Jun-amino-terminal kinase-interacting protein 1 , IB-1 , JNK MAP kinase scaffold protein 1 , JNK-interacting protein 1 , islet-brain-1 , mitogen activated protein kinase 8 interacting protein 1 , mitogen-activated protein kinase 8-interacting protein 1 , protein kinase, mitogen-activated 8 interacting protein , JIP-1-related protein , JRP , mitogen activated protein kinase 8 interacting protein , PRKM8 interacting protein , islet-brain 1 , islet brain 1

GENE ID SPECIES
423202 Gallus gallus
100344706 Oryctolagus cuniculus
100473891 Ailuropoda melanoleuca
19099 Mus musculus
116457 Rattus norvegicus
9479 Homo sapiens
483640 Canis lupus familiaris
524806 Bos taurus
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