anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Anticorps

mouse homolog regulates pattern formation during embryogenesis. De plus, nous expédions Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MLLT3 4300 P42568
MLLT3 70122 A2AM29
MLLT3 114510  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Anticorps sur anticorps-enligne.fr

Showing 10 out of 84 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-MLLT3 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB <b>WB Suggested Anti-MLLT3 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué WB The anti-MLLT3 Pab (ABIN390129) is used in Western blot to detect MLLT3 in mouse cerebellum tissue lysate MLLT3 Antibody (C-term) (ABIN390129) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the MLLT3 antibody detected the MLLT3 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of AF9 (MLLT3) Antibody (C-term K486) (ABIN390128) in 293 cell line lysates (35 µg/lane). MLLT3(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué EIA, WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), IP, WB Detection of Human AF9 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 10 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-AF9 antibody ABIN151110 used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B), and used for IP at 3 mcg/mg lysate. AF9 was also immunoprecipitated using rabbit anti-AF9 antibodies ABIN151108, ABIN151109 and another AF9 Ab at 3 mcg/mg lysate. Detection: Chemiluminescence with exposure times of 30 seconds (A and B). 100 μL Connectez-vous pour afficher 7 to 9 Days
$486.94
Détails
Boeuf (Vache) Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$551.83
Détails
Humain Lapin Inconjugué WB The anti-MLLT3 Pab (ABIN390130) is used in Western blot to detect MLLT3 in HL60 tissue lysate 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails

MLLT3 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , ,
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Mouse (Murine)


Rat (Rattus)


anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Anticorps mieux référencés

  1. Human Polyclonal MLLT3 Primary Antibody pour ICC, IF - ABIN151110 : Lin, Hemenway: Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. dans The Journal of biological chemistry 2010 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal MLLT3 Primary Antibody pour IHC (p), WB - ABIN390128 : Iida, Seto, Yamamoto, Komatsu, Tojo, Asano, Kamada, Ariyoshi, Takahashi, Ueda: MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. dans Oncogene 1993 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal MLLT3 Primary Antibody pour EIA, IHC (p) - ABIN358673 : Bitoun, Oliver, Davies: The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. dans Human molecular genetics 2007 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 partenaires d’interaction

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. MLL (Montrer MLL Anticorps)-AF9 fusion is associated with acute myeloid leukemia (Montrer BCL11A Anticorps).

  2. Structural insights into H3 histone (Montrer HIST1H3B Anticorps) crotonyl-lysine recognition by the AF9 YEATS domain have been presented.

  3. A luciferase reporter gene assay revealed that hsp70 promoter activation is enhanced by the transcriptional co-activator AF9 and splicing mediator SNRPE, but suppressed by the coiled-coil domain-containing protein CCDC127.

  4. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  5. Results show that human MLL (Montrer MLL Anticorps)-AF9 expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (Montrer BCL11A Anticorps) that expresses genes related to epithelial-mesenchymal transition.

  6. Results show that MLL (Montrer MLL Anticorps)-AF9 reduces Id2 and increases E2-2 (Montrer TCF4 Anticorps) expression to drive and sustain leukemia stem cell potential in MLL (Montrer MLL Anticorps)-rearranged acute myeloid leukemia (Montrer BCL11A Anticorps) (AML (Montrer RUNX1 Anticorps)). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL (Montrer MLL Anticorps)-rearranged but also t(8;21) AML (Montrer RUNX1 Anticorps) patients.

  7. Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations.

  8. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L (Montrer DOT1L Anticorps)-mediated H3K79 methylation in transcription control.

  9. AF9 and its homolog ENL directly interact with AF4.

  10. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (Montrer KAT6B Anticorps) cells harbouring the MLL (Montrer MLL Anticorps)-AF9 oncogene (Montrer RAB1A Anticorps).

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) interaction partners

  1. Atg5 (Montrer ATG5 Anticorps)-dependent autophagy contributes to the development of acute myeloid leukemia (Montrer BCL11A Anticorps) in an MLL (Montrer MLL Anticorps)-AF9-driven mouse model.

  2. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  3. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  4. Using a PDK1 (Montrer PDPK1 Anticorps) conditional deletion MLL (Montrer MLL Anticorps)-AF9 murine AML (Montrer RUNX1 Anticorps) model, we revealed that the deletion of PDK1 (Montrer PDPK1 Anticorps) prolonged the survival of AML (Montrer RUNX1 Anticorps) mice by inducing LSC (Montrer ARHGEF1 Anticorps) apoptosis

  5. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (Montrer MLLT1 Anticorps)/3 and AFF proteins that is critically important for MLL (Montrer MLL Anticorps)-mediated transformation of HPCs

  6. Af9 mediates site-selective physical and functional recruitment of Rnf2 (Montrer RNF2 Anticorps) to the alpha-ENaC (Montrer SCNN1A Anticorps) promoter to constrain basal alpha-ENaC (Montrer SCNN1A Anticorps) transcription in collecting duct cells.

  7. Impaired alphaENaC (Montrer SCNN1A Anticorps) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  8. We demonstrate that leukemogenic activity of MLL (Montrer MLL Anticorps)-AF9 requires RUVBL2 (RuvB-like 2 (Montrer RUVBL2 Anticorps)), an AAA (Montrer AAAS Anticorps)+ ATPase (Montrer DNAH8 Anticorps) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  9. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (Montrer EDN1 Anticorps) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  10. It was concluded that +78/+92 of the epithelial Na+ channel alpha (Montrer SCNN1A Anticorps)-subunit (Montrer POLG Anticorps) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (Montrer POLG Anticorps) transcription.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) profil antigène

Profil protéine

mouse homolog regulates pattern formation during embryogenesis

Gene names and symbols associated with MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3) anticorps
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) anticorps
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3) anticorps
  • 2210011H10Rik anticorps
  • 2610012I03Rik anticorps
  • 3830408D16Rik anticorps
  • Af-9 anticorps
  • Af9 anticorps
  • D4Ertd321e anticorps
  • fc39c11 anticorps
  • wu:fc39c11 anticorps
  • YEATS3 anticorps
  • zgc:110210 anticorps

Protein level used designations for MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPECIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
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