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anti-Neurofibromin 2 (NF2) Anticorps

NF2 encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. De plus, nous expédions Neurofibromin 2 Kits (14) et Neurofibromin 2 Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
NF2 18016 P46662
NF2 4771 P35240
NF2 25744 Q63648
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Top anti-Neurofibromin 2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 171 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IF, IHC (p), WB Western blot analysis of Merlin Antibody (N-term) (ABIN390756) in NCI-H460 cell line lysates (35 µg/lane). NF2 (arrow) was detected using the purified polyclonal antibody. Merlin Antibody (N-term) (ABIN390756) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells treated with IFN 2500U/ml 30', using Merlin (Phospho-Ser10) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Merlin (Phospho-Ser10) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of Merlin Antibody (N-term) in NCI-H460 cell line lysates (35ug/lane). NF2 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from RAW264.7 cells, using Merlin (Ab-10) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué IP, IHC, ELISA, WB 100 μg Connectez-vous pour afficher 5 to 7 Days
412,76 €
Détails
Humain Lapin Inconjugué EIA, WB Immunoblotting. Affinity purified phosphospecific antibody to NF2 (Merlin) at pS518 was used at a 1:1000 dilution to detect NF2 by Western blot. Approximately 12 ul of a mouse cardiac myocyte lysate was loaded per lane on a 4-20% Criterion gel for SDS-PAGE. Samples were either mock treated (lane 1) or CLA treated at 4nM, 20 nM or 100 nM (lanes 2,3 and 4 respectively) for 45'. After washing, a 1:5,000 dilution of HRP conjugated Gt-a- Rabbit IgG preceded color development using Amersham's substrate system. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué IHC (p), WB 0.1 mL Connectez-vous pour afficher 8 to 10 Days
352,00 €
Détails
Humain Lapin Inconjugué IF, WB 0.1 mL Connectez-vous pour afficher 8 to 10 Days
352,00 €
Détails
Poisson Zèbre Chèvre Inconjugué EIA, IHC (p)   0.1 mg Connectez-vous pour afficher 8 to 10 Days
385,00 €
Détails
Poulet Chèvre Inconjugué EIA, IHC (p) 50 μg Connectez-vous pour afficher 8 to 10 Days
517,00 €
Détails

NF2 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Neurofibromin 2 Anticorps mieux référencés

  1. Human Polyclonal NF2 Primary Antibody pour IHC (p), WB - ABIN197520 : Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. dans Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for ABIN197520

  2. Human Polyclonal NF2 Primary Antibody pour IF, WB - ABIN197028 : Yang, Hinds: Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. dans Cancer research 2006 (PubMed)
    Show all 4 references for ABIN197028

  3. Human Polyclonal NF2 Primary Antibody pour IHC, ELISA - ABIN1532019 : Yu, Zeidel, Hill: Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast. dans PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN1532019

  4. Human Polyclonal NF2 Primary Antibody pour EIA, WB - ABIN117953 : Gutmann, Wright, Geist, Snider: Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. dans Human molecular genetics 1995 (PubMed)
    Show all 2 references for ABIN117953

  5. Human Polyclonal NF2 Primary Antibody pour IP, IHC - ABIN104130 : Wang, Lu, Tang, Wang, Wu: The phosphorylation status of merlin in sporadic vestibular Schwannomas. dans Molecular and cellular biochemistry 2009 (PubMed)
    Show all 2 references for ABIN104130

  6. Human Polyclonal NF2 Primary Antibody pour ELISA, WB - ABIN1533058 : Trofatter, MacCollin, Rutter, Murrell, Duyao, Parry, Eldridge, Kley, Menon, Pulaski: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. dans Cell 1993 (PubMed)
    Show all 2 references for ABIN1533058

  7. Zebrafish (Danio rerio) Polyclonal NF2 Primary Antibody pour EIA, IHC (p) - ABIN401528 : Sadler, Amsterdam, Soroka, Boyer, Hopkins: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. dans Development (Cambridge, England) 2005 (PubMed)

  8. Human Polyclonal NF2 Primary Antibody pour EIA, WB - ABIN453191 : James, Han, Polizzano, Plotkin, Manning, Stemmer-Rachamimov, Gusella, Ramesh: NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. dans Molecular and cellular biology 2009 (PubMed)

Plus d’anticorps contre Neurofibromin 2 partenaires d’interaction

Zebrafish Neurofibromin 2 (NF2) interaction partners

  1. Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct

Mouse (Murine) Neurofibromin 2 (NF2) interaction partners

  1. loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (Montrer NGFR Anticorps)) expression.

  2. Loss of Nf2 and Cdkn2a (Montrer CDKN2A Anticorps)/b have synergistic effects with PDGF-B (Montrer PDGFB Anticorps) overexpression promoting meningioma malignant transformation.

  3. Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation

  4. Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.

  5. Merlin and Ezrin (Montrer EZR Anticorps) are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (Montrer EGFR Anticorps).

  6. The study describe a novel NF2 mouse model recapitulating schwannoma phenotypes found in human patients where tumors develop in the cranial nerve VIII (Montrer COX8A Anticorps) and/or the spinal roots.

  7. Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2 (Montrer ERBB2 Anticorps)-dependent manner.

  8. Nf2-Yap signaling plays important roles in controlling the expansion of dorsal root ganglia progenitors and glia during DRG development

  9. CD44 (Montrer CD44 Anticorps) cytoplasmic tail cleaved by RIP (Montrer HRB Anticorps) could release DCAF1 (Montrer VPRBP Anticorps) from merlin by competing for binding to the merlin FERM domain, which results in the inhibition of merlin-mediated suppression of tumorigenesis.

  10. Findings indicate that merlin is sumoylated and that this post-translational modification is essential for tumor suppression.

Human Neurofibromin 2 (NF2) interaction partners

  1. Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2), LATS2 (Montrer LATS2 Anticorps) (large tumor suppressor (Montrer LATS1 Anticorps) kinase 2), and YAP (Montrer YAP1 Anticorps)/TAZ (Montrer TAZ Anticorps) (nuclear translocation of complex of Yes-associated protein [YAP (Montrer YAP1 Anticorps)] with transcriptional coactivator with PDZ-binding motif (Montrer WWTR1 Anticorps) [TAZ (Montrer TAZ Anticorps)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.

  2. The mortality of patients with NF2 diagnosed in more recent decades was lower than that of patients diagnosed earlier.

  3. AMOTL1 (Montrer AMOTL1 Anticorps) Promotes Breast Cancer Progression and Is Antagonized by Merlin

  4. homozygous deletions in CDKN2A (Montrer CDKN2A Anticorps) and hemizygous loss of NF2 as detected by fluorescence in situ hybridization would confer a poor clinical outcome and may guide future treatment decisions for patients with peritoneal mesothelioma.

  5. NF2/merlin inactivation augments mutant RAS signaling by promoting YAP (Montrer YAP1 Anticorps)/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK (Montrer MAPK1 Anticorps) output and increased sensitivity to MEK (Montrer MAP2K1 Anticorps) inhibitors.

  6. Loss of Nf2 and Cdkn2a (Montrer CDKN2A Anticorps)/b have synergistic effects with PDGF-B (Montrer PDGFB Anticorps) overexpression promoting meningioma malignant transformation.

  7. we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP (Montrer YAP1 Anticorps)-dependent induction of CYR61/CCN1 (Montrer CYR61 Anticorps) and miR (Montrer MLXIP Anticorps)-296-3p.

  8. angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling

  9. (Delta2-4)Merlin variant disrupts the normal function of Merlin and promotes hepatocellular carcinoma metastasis.

  10. Stusies indicate that monosomy 22, which is often associated with mutations of the neurofibromin 2 (NF2) gene, has emerged as the most frequent alteration of meningiomas.

Neurofibromin 2 (NF2) profil antigène

Profil protéine

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Gene names and symbols associated with anti-Neurofibromin 2 (NF2) Anticorps

  • neurofibromin 2b (merlin) (nf2b) anticorps
  • neurofibromin 2 (bilateral acoustic neuroma) (NF2) anticorps
  • neurofibromin 2 (merlin) (NF2) anticorps
  • neurofibromin 2 (NF2) anticorps
  • neurofibromin 2 (LOC100357691) anticorps
  • merlin-like (LOC417537) anticorps
  • neurofibromatosis 2 (Nf2) anticorps
  • neurofibromin 2 (merlin) (Nf2) anticorps
  • neurofibromin 2a (merlin) (nf2a) anticorps
  • ACN anticorps
  • BANF anticorps
  • merlin anticorps
  • NF2 anticorps
  • NF2a anticorps
  • SCH anticorps
  • zgc:194620 anticorps
  • zgc:194631 anticorps

Protein level used designations for anti-Neurofibromin 2 (NF2) Anticorps

neurofibromin 2 (bilateral acoustic neuroma) , merlin , neurofibromatosis 2 , neurofibromin 2 , moesin-ezrin-radixin-like protein , neurofibromin-2 , schwannomin , moesin-ezrin-radixin like , moesin-ezrin-radizin-like protein , schwannomerlin

GENE ID SPECIES
405887 Danio rerio
395158 Gallus gallus
100058977 Equus caballus
100329097 Saccoglossus kowalevskii
100357691 Oryctolagus cuniculus
417537 Gallus gallus
18016 Mus musculus
4771 Homo sapiens
25744 Rattus norvegicus
477535 Canis lupus familiaris
100520699 Sus scrofa
540479 Bos taurus
561184 Danio rerio
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