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anti-Human MAS1 Anticorps:
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Human Polyclonal MAS1 Primary Antibody pour ICC, IF - ABIN270653
Bosnyak, Widdop, Denton, Jones: Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats. dans International journal of hypertension 2011
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Human Polyclonal MAS1 Primary Antibody pour ICC, IF - ABIN4332754
da Silveira, Coelho, Vieira, Sachs, Barroso, Costa, Bretas, Bader, de Sousa, da Silva, dos Santos, Simões e Silva, Teixeira: Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis. dans Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Polyclonal MAS1 Primary Antibody pour IHC, IHC (p) - ABIN4892714
Wang, Liang, Leung: The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos. dans PLoS ONE 2015
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
Here, we review the role and effects of ACE2 (Montrer ACE2 Anticorps), ACE2 (Montrer ACE2 Anticorps) activators, Ang-(1 (Montrer ANGPT1 Anticorps)-7) and synthetic Mas receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (Montrer ACE Anticorps)-Ang II (Montrer AGT Anticorps)-AT1 (Montrer AGTR1 Anticorps) axis.
Downregulation of ACE2 (Montrer ACE2 Anticorps)/Ang-(1 (Montrer ANGPT1 Anticorps)-7)/Mas axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (Montrer PAK1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps)/Snail1 (Montrer SNAI1 Anticorps) pathways.
These results indicated that angiotensin-(1-7)/ACE2/Mas axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM signaling pathway.
Ang-(1 (Montrer ANGPT1 Anticorps)-7) downregulated AT1R (Montrer AGTR1 Anticorps) mRNA, upregulated mRNA levels of Ang II (Montrer AGT Anticorps) type 2 receptor (AT2R (Montrer AGTR2 Anticorps)) and Mas receptor (MasR) and p38-MAPK (Montrer MAPK14 Anticorps) phosphorylation and suppressed H22 cell-endothelial cell communication
MAS1 might act as an inhibitory regulator of breast cancer.
Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist.
Data suggest that angiotensin converting enzyme 2 (Montrer ACE2 Anticorps)/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW]
Up-regulation of the ACE2 (Montrer ACE2 Anticorps)/Ang-(1 (Montrer ANGPT1 Anticorps)-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK (Montrer MAPK1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) pathway.
A proximal promoter construct for the MAS gene was repressed by the SOX (Montrer PIPOX Anticorps) [SRY (Montrer SRY Anticorps) (sex-determining region on the Y chromosome) box] proteins SRY (Montrer SRY Anticorps), SOX2 (Montrer SOX2 Anticorps), SOX3 (Montrer SOX3 Anticorps) and SOX14 (Montrer SOX14 Anticorps), of which SRY (Montrer SRY Anticorps) is known to interact with the KRAB domain.
Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function
MasR deficiency abolishes protection of female mice from obesity-induced hypertension
Results suggest that angiotensin converting enzyme 2 (Montrer ACE2 Anticorps) may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
impairment of the ANG-(1 (Montrer ANGPT1 Anticorps)-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma.
The data indicate a significant function of Ang-(1 (Montrer ANGPT1 Anticorps)-7) in the regulation of insulin (Montrer INS Anticorps) secretion from mouse islets in vitro and in vivo, mainly, but not exclusively, by Mas-dependent signaling, modulating the accessory pathway of insulin (Montrer INS Anticorps) secretion via increase in cAMP.
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR.
Ang-(1 (Montrer ANGPT1 Anticorps)-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate.
Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II (Montrer AGT Anticorps)-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2 (Montrer ACE2 Anticorps)-angiotensin-(1-7)-MAS axis functionality
Mas receptor deficiency results in exacerbated inflammation in LPS (Montrer TLR4 Anticorps)-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS (Montrer TLR4 Anticorps).
a Mas receptor-mediated mechanism may stimulate pancreatic cell development
oncogene\; may be involved in function or development of neural tissues
, MAS proto-oncogene
, angiotensin-(1-7) receptor
, MAS1 oncogene