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Aperçu des produits pour anti-ITCH (ITCH) Anticorps

Full name:
anti-Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) Anticorps (ITCH)
Chez www.anticorps-enligne.fr sont 72 Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) Anticorps de 19 de différents fournisseurs disponibles. De plus, nous expédions ITCH Protéines (6) et ITCH Kits (3) et beaucoup plus de produits pour cette protéine. Un total de 90 ITCH produits sont actuellement listés.
Synonymes:
6720481N21Rik, 8030492O04Rik, A130065M08, AIF4, AIP4, C230047C07Rik, dJ468O1.1, NAPP1
afficher tous les anticorps Gène GeneID UniProt
ITCH 83737 Q96J02
ITCH 16396 Q8C863
ITCH    

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Réactivités les plus populaires pour anti-ITCH (ITCH) Anticorps

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anti-Human ITCH Anticorps:

anti-Mouse (Murine) ITCH Anticorps:

anti-Rat (Rattus) ITCH Anticorps:

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anti-ITCH Anticorps mieux référencés

  1. Human Polyclonal ITCH Primary Antibody pour ELISA, WB - ABIN1533142 : Chen, Wen, Fukuda, Gavva, Hsu, Akama, Yang-Feng, Shen: Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. dans Genomics 2001 (PubMed)
    Show all 2 references for ABIN1533142

  2. Human Polyclonal ITCH Primary Antibody pour IHC, ELISA - ABIN1532110 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... dans Nature 2002 (PubMed)
    Show all 2 references for ABIN1532110

  3. Human Polyclonal ITCH Primary Antibody pour ICC, IF - ABIN4327763 : Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: Novel signatures of cancer-associated fibroblasts. dans International journal of cancer 2013 (PubMed)

  4. Human Polyclonal ITCH Primary Antibody pour ELISA, WB - ABIN261096 : Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. dans Nature cell biology 2006 (PubMed)

  5. Human Monoclonal ITCH Primary Antibody pour IF, WB - ABIN968414 : Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. dans Nature genetics 1998 (PubMed)

  6. Mouse (Murine) Polyclonal ITCH Primary Antibody pour WB - ABIN657549 : Lohr, Molleston, Strauss, Torres-Martinez, Sherman, Squires, Rider, Chikwava, Cummings, Morton, Puffenberger: Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. dans American journal of human genetics 2010 (PubMed)

Plus d’anticorps contre ITCH partenaires d’interaction

Human Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. Results indicate that TAX1BP1 (Montrer TAX1BP1 Anticorps) functions as an adaptor molecule for Itch to target MAVS (Montrer MAVS Anticorps) during RNA virus infection and thus restrict virus-induced apoptosis.

  2. These data demonstrate that Itch, ubiquitin, and Alix (Montrer PDCD6IP Anticorps) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.

  3. The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain (Montrer DRP2 Anticorps) of the host E3 ubiquitin ligase (Montrer MUL1 Anticorps) ITCH.

  4. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.

  5. cir (Montrer KCNJ5 Anticorps)-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression

  6. Itch monoubiquitinates SMN (Montrer STMN1 Anticorps) and monoubiquitination of SMN (Montrer STMN1 Anticorps) plays an important role in regulating its cellular localization.

  7. miR (Montrer MLXIP Anticorps)-106b, which itself is down regulated in metastatic pancreatic cancer, directly interacts and inhibits ITCH expression.

  8. LRAD3 is a component of pathways that function effectively to modulate Itch and Nedd4 auto-ubiquitination and levels.

  9. Cytomegalovirus UL42 induced the ubiquitination and degradation of human Itch in virus-infected fibroblasts, and was partially colocalized with p62 (Montrer GTF2H1 Anticorps), a ubiquitin-binding protein, and CD63 (Montrer CD63 Anticorps), a marker of lysosome and multivesicular bodies.

  10. catalytic activity of Itch toward different SH3 domain (Montrer ITSN1 Anticorps)-containing proteins was similar, except for beta-PIX (Montrer ARHGEF7 Anticorps) that was not readily ubiquitylated even though it could interact with an affinity comparable to those of other substrates tested

Mouse (Murine) Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) interaction partners

  1. this study identified a previously unknown role for Itch in regulating IL-17 (Montrer IL17A Anticorps)-mediated colonic inflammation and carcinogenesis

  2. Itch monoubiquitinates SMN (Montrer STMN1 Anticorps) and monoubiquitination of SMN (Montrer STMN1 Anticorps) plays an important role in regulating its cellular localization.

  3. ITCH targets TXNIP (Montrer TXNIP Anticorps) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (Montrer TXN Anticorps) system.

  4. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.

  5. Impaired ITCH results in heightened TNF (Montrer TNF Anticorps) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (Montrer TNF Anticorps) signaling is genetically deleted.

  6. ITCH modulates SIRT6 (Montrer SIRT6 Anticorps) and SREBP2 (Montrer SREBF2 Anticorps) to influence lipid metabolism and atherosclerosis in ApoE (Montrer APOE Anticorps) null mice

  7. In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.

  8. The E3 ubiquitin ligase (Montrer MUL1 Anticorps) Itch inhibits p38alpha (Montrer MAPK14 Anticorps) signaling and skin inflammation through the ubiquitylation of Tab1 (Montrer TAB1 Anticorps).

  9. Ndfip1 (Montrer NDFIP1 Anticorps) regulates itch ligase activity and airway inflammation via UbcH7 (Montrer UBE2L3 Anticorps).

  10. The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (Montrer FOXP3 Anticorps) expression independently of Itch.

ITCH profil antigène

Antigen Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with ITCH

  • itchy E3 ubiquitin protein ligase (ITCH) anticorps
  • itchy, E3 ubiquitin protein ligase (Itch) anticorps
  • 6720481N21Rik anticorps
  • 8030492O04Rik anticorps
  • A130065M08 anticorps
  • AIF4 anticorps
  • AIP4 anticorps
  • C230047C07Rik anticorps
  • dJ468O1.1 anticorps
  • NAPP1 anticorps

Protein level used designations for ITCH

E3 ubiquitin-protein ligase Itchy homolog , NFE2-associated polypeptide 1 , atrophin-1 interacting protein 4 , dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) , itchy E3 ubiquitin protein ligase homolog , E3 ubiquitin-protein ligase Itchy

GENE ID SPECIES
83737 Homo sapiens
16396 Mus musculus
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