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CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) anticorps (FITC)

Détails pour le produit réf. ABIN118795, Fournisseur: Connectez-vous pour afficher
Antigène
  • CD79A
  • Ig-alpha
  • Iga
  • Igalpha
  • Ly-54
  • Ly54
  • mb-1
  • IGA
  • MB-1
  • IG-alpha
Reactivité
Humain
252
82
43
39
38
32
30
30
27
21
17
9
6
3
3
3
3
3
3
2
Hôte
Souris
169
112
4
1
Clonalité (Clone)
Monoclonal ()
Conjugué
FITC
26
25
15
13
7
5
2
2
2
1
1
1
1
1
Application
Flow Cytometry (FACS)
132
121
69
63
53
24
23
19
6
4
4
4
3
2
2
1
1
1
1
Fournisseur
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Supplier Product No.
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Images

Immunogène IgM complex isolated from Daudi cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone ZL7-4
Isotype IgG1
Specificité This antibody reacts with CD79a positive cells by flow cytometry. This clone has been reported to be useful in distinguishing B-CLL from mantle cell lymphoma in flow cytometric assays.
Autre désignation CD79a (CD79A Antibody Extrait)
Sujet A disulfide-linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, is non-covalently associated with membrane bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling.Synonyms: B-Cell marker, B-cell antigen receptor complex-associated protein alpha-chain, IGA, MB-1 membrane glycoprotein, MB1, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein
ID gène 973
NCBI Accession NP_001774
UniProt P11912
Domaine de recherche Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways
Indications d'application Flow Cytometry: Use 10 μL of neat antibody to label 1x10^6 cells in 100 μL. We recommend incubation times of at least 30 minutes with this antibody.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) anticorps (FITC) (ABIN118795) Staining of RAMOS cells with MOUSE ANTI HUMAN CD79a:FITC (ABIN118795).
Reference: Background Bell, Rooney, Bosanquet: "CD79a detected by ZL7.4 separates chronic lymphocytic leukemia from mantle cell lymphoma in the leukemic phase." dans: Cytometry, Vol. 38, Issue 3, pp. 102-5, 1999 (PubMed).

Zhang, French, Chan et al.: "The development of anti-CD79 monoclonal antibodies for treatment of B-cell neoplastic disease." dans: Therapeutic immunology, Vol. 2, Issue 4, pp. 191-202, 1997 (PubMed).