anticorps apg4b, anticorps APG4B, anticorps AUTL1, anticorps 2510009N07Rik, anticorps AW048066, anticorps Apg4b, anticorps Atg4bl, anticorps Autl1, anticorps Aut2b2, anticorps autophagy related 4B cysteine peptidase, anticorps autophagy-related 4b, anticorps Peptidase family C54 protein, anticorps cysteine protease ATG4B, anticorps ATG4 autophagy related 4 homolog B (S. cerevisiae), anticorps autophagy related 4B, cysteine peptidase, anticorps autophagy related 4B, cysteine peptidase L homeolog, anticorps ATG4B, anticorps Atg4b, anticorps AT3G59950, anticorps Tsp_08582, anticorps Tsp_11599, anticorps atg4b, anticorps atg4b.L
Sujet
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.Synonyms: AUT-like 1 cysteine endopeptidase, AUTL1, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, Cysteine protease ATG4B, KIAA0943