Glutaredoxin 2 anticorps (GRX2) (HRP)

Details for Product anti-GRX2 Antibody No. ABIN1712066, Fournisseur: Connectez-vous pour afficher
Antigène
  • ECK1049
  • JW1051
  • CGI-133
  • GRX2
  • 1700010P22Rik
  • AI645710
  • Grx2
  • glutaredoxin 2 (Grx2)
  • glutaredoxin Grx2
  • glutaredoxin (grx-2)
  • glutaredoxin 2
  • glutaredoxin 2 (thioltransferase)
  • grxB
  • grx2
  • grx-2
  • GLRX2
  • Glrx2
Reactivité
Humain
55
11
9
2
2
2
2
2
2
1
Hôte
Lapin
45
10
Clonalité
Polyclonal
Conjugué
Cet anticorp Glutaredoxin 2 est conjugé à/à la HRP
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
28
13
10
10
9
8
8
5
3
2
2
Options
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
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Immunogène KLH conjugated synthetic peptide derived from human Glutaredoxin 2
Isotype IgG
Purification Purified by Protein A.
Autre désignation Glutaredoxin 2 (GRX2 Antibody Extrait)
Sujet

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Subcellular location: Nucleus, Mitochondrion

Synonyms: GRX2, CGI-133, Glutaredoxin-2, mitochondrial, GLRX2

ID gène 51022
UniProt Q9NS18
Pathways Cell RedoxHomeostasis
Indications d'application IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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