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EYA2 anticorps (Eyes Absent Homolog 2 (Drosophila)) (HRP)

Détail du produit anti-EYA2 anticorps No. ABIN1712262, Fournisseur: Connectez-vous pour afficher
Antigène
  • EYA2
  • zgc:92279
  • eab1
  • Eab1
  • EAB1
  • eyes absent homolog 2 (Drosophila)
  • eyes absent homolog 2
  • eyes absent 2 homolog (Drosophila)
  • EYA2
  • eya2
  • LOC100218165
  • Eya2
Reactivité
Humain, Souris, Rat (Rattus)
79
21
19
4
3
2
1
1
Hôte
Lapin
65
14
Clonalité
Polyclonal
Conjugué
Cet anticorp EYA2 est conjugé à/à la HRP
7
7
6
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
58
39
13
12
10
8
8
4
Options
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Immunogène KLH conjugated synthetic peptide derived from human EYA2
Isotype IgG
Purification Purified by Protein A.
Autre désignation Eya2 (EYA2 Antibody Extrait)
Sujet

A gene on chromosome 20q13.1 encodes Eya2 (eyes absent). EYA2 is one of four members of the eyes absent family. A 271 amino acid domain at the carboxy-terminal is highly conserved amongst the members of the eyes absent family, while the PST (proline-serive-threonin)-rich amino-terminal is highly divergent. EYA2 is expressed relatively late in development in the cytoplasm of extensor tendons and ligaments of the phalangeal elements of the limb, cranial placodes, branchial arches, central nervous system, and the developing eye. Pax3 induces the expression of Eya2 in a cascade that is necessary and sufficient for myogenesis. EYA2, like EYA1, acts as a transcriptional activator in connective tissue patterning through its PST domain, which functions as a transactivation domain. EYA2 is translocated to the nucleus by Six proteins, which interact through their domain and homeodomain with EYA2. EYA2 carboxy-terminal interacts with the G Alpha z and G Alphai 2 proteins. This interaction prevents Six proteins from translocating EYA2 to the nucleus.


Synonyms: EAB 1, EAB1, EYA 2, EYA2, EYA2_HUMAN, eyes absent 2 homolog Drosophila, Eyes absent homolog 2, Translation of this uORF probably lowers the translation efficiency of EYA2.
ID gène 2139
Domaine de recherche Chromatin and Nuclear Signaling, Transcription Factors
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months