This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
Synonyms: Galectin-3, 35 kDa lectin, Carbohydrate binding protein 35, CBP 35, CBP35, GAL 3, GAL3, Galactose specic lectin 3, Galactose-specic lectin 3, Galactoside binding protein, Galactoside-binding protein, GALBP, Galectin3 internal gene,included, Galectin-3, Galectin3, GALIG, GBP, IgE binding protein, IgE-binding protein, L 31, L 34, L-34 galactoside-binding lectin, L31, Laminin binding protein, Laminin-binding protein, Lectin galactose binding soluble 3, Lectin galactoside binding soluble 3, Lectin L 29, Lectin L-29, Lectin, galactose binding, soluble 3, LGALS 3, LGALS2, LGALS3, LGALS3 protein, MAC 2 antigen, Mac-2, MAC2, Macrophage galactose-specic lectin, MGC105387, Galectin- 3, LEG3_MOUSE.