This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This SMAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SMAD1.
SMAD1
Reactivité: Humain, Souris, Rat
WB, IF, IHC (p)
Hôte: Lapin
Polyclonal
RB43846
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Ye, Yu, Hu, Lu, Xie: "Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma." dans: Journal of experimental & clinical cancer research : CR, Vol. 29, pp. 78, (2010) (PubMed).
Yang, Li, Al-Lamki, Southwood, Zhao, Lever, Grimminger, Schermuly, Morrell: "Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo." dans: Circulation research, Vol. 107, Issue 2, pp. 252-62, (2010) (PubMed).
Smythies, Shen, Bimczok, Novak, Clements, Eckhoff, Bouchard, George, Hu, Dandekar, Smith: "Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation." dans: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 19593-604, (2010) (PubMed).
Abhishek, Kumar, Arif, Patra, Choudhary, Sohail: "Induced expression of bone morphogenetic protein-6 and Smads signaling in human monocytes derived dendritic cells during sickle-cell pathology with orthopedic complications." dans: Biochemical and biophysical research communications, Vol. 396, Issue 4, pp. 950-5, (2010) (PubMed).
Antigène
SMAD1
(SMAD, Mothers Against DPP Homolog 1 (SMAD1))
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.