This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This TICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Nakajima, Ohtani, Satta, Uno, Akari, Ishida, Kimura: "Natural selection in the TLR-related genes in the course of primate evolution." dans: Immunogenetics, Vol. 60, Issue 12, pp. 727-35, (2008) (PubMed).
Bin, Xu, Shu: "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling." dans: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 24526-32, (2003) (PubMed).
Oshiumi, Matsumoto, Funami, Akazawa, Seya: "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction." dans: Nature immunology, Vol. 4, Issue 2, pp. 161-7, (2003) (PubMed).
Matsuda, Suzuki, Honda, Muramatsu, Matsuzaki, Nagano, Doi, Shimotohno, Harada, Nishida, Hayashi, Sugano: "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." dans: Oncogene, Vol. 22, Issue 21, pp. 3307-18, (2003) (PubMed).
Yamamoto, Sato, Mori, Hoshino, Takeuchi, Takeda, Akira: "Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 12, pp. 6668-72, (2002) (PubMed).
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.