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CASP5 anticorps

CASP5 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN319133
  • Antigène Voir toutes CASP5 Anticorps
    CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
    Reactivité
    • 45
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 42
    • 3
    Lapin
    Clonalité
    • 34
    • 11
    Polyclonal
    Conjugué
    • 28
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp CASP5 est non-conjugé
    Application
    • 27
    • 15
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Specificité
    This antibody recognises an epitope located within the internal region of human Caspase-5, a 47 kDa cysteine protease, otherwise known as ICH-3.
    Purification
    Antisera to human Caspase-5 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
    Immunogène
    A 14 amino acid peptide from the centre of human Caspase-5.
    Isotype
    IgG
  • Indications d'application
    Western Blot: 1.0g/mL - 2.0g/mL, detects a band of approximately 48 kDa in Ramos celllysates. (Predicted precursor MWT 47.8 kDa)
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline containing 0.02 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
    Autre désignation
    Caspase-5 (CASP5 Produits)
    Synonymes
    anticorps ICE(rel)III, anticorps ICEREL-III, anticorps ICH-3, anticorps CASP5, anticorps caspase 5, anticorps caspase-5, anticorps CASP5, anticorps LOC100437308
    Sujet
    Caspase-5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes. Caspase-5 is a member of a growing number of inflammatory caspases belonging to the Caspase-1 (ICE-type) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase-1, Caspase-5 is not directly responsible for the activation of IL-1Beta from the pro-IL-1Beta precursor, but the presence of Caspase-5 does appear to enhance the processing of IL-1Beta. The in vivo expression of Caspase-5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma (IFNg). In vitro studies have shown cleavage of Caspase-5 by the serine protease Granzyme B, which plays a major role in Cytotoxic T lymphocyte (CTL)-induced apoptosis (1).Synonyms: CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease
    ID gène
    838
    NCBI Accession
    NP_001129581
    UniProt
    P51878
    Pathways
    Inflammasome
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