CD14 anticorps (AA 147-152)

N° du produit ABIN343170

Cité dans 3 publications. Cet anticorps anti-CD14 Monoclonal Souris (Clone biG2) (ABIN343170) détecte spécifiquement CD14 dans FACS, IF et Agon. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CD14 anticorps (AA 147-152) (ABIN343170)

Antigène: CD14

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD14 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Agonist (Agon)

Clone: BiG2

Détail du produit anti-CD14 anticorps

Épitope: AA 147-152

Specificité: Soluble and membrane bound human CD14. The antibody does'nt significant block LPS binding to membrane bound CD14.

Purification: Protein G affinity column

Immunogène: human Monocytes

Isotype: IgG1

Information d'application

Indications d'application: no significant inhibition of LPS binding to CD14

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with bidistilled water

Concentration: 1 mg/mL

Buffer: PBS, pH 7.7

Agent conservateur: Without preservative

Stock: -20 °C,-80 °C

Références pour anticorps anti-CD14 (ABIN343170)

Stelter, Loppnow, Menzel, Grunwald, Bernheiden, Jack, Ulmer, Schuett: "Differential impact of substitution of amino acids 9-13 and 91-101 of human CD14 on soluble CD14-dependent activation of cells by lipopolysaccharide." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 11, pp. 6035-44, (1999) (PubMed).

Dziarski, Tapping, Tobias: "Binding of bacterial peptidoglycan to CD14." dans: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8680-90, (1998) (PubMed).

Neumeister, Faigle, Sommer, Zaehringer, Stelter, Menzel, Schuett, Northoff: "Low endotoxic potential of Legionella pneumophila lipopolysaccharide due to failure of interaction with the monocyte lipopolysaccharide receptor CD14." dans: Infection and immunity, Vol. 66, Issue 9, pp. 4151-7, (1998) (PubMed).

Détails sur CD14

Antigène: CD14

Autre désignation: CD14

Sujet: Background: biG 2 represents an excellent marker for CD14. The CD14 glycoprotein, gp 55, is present on most monocytic and macrophages like cell types: monocytes, macrophages, weekly at surface of neutrophiles like Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 Molecule has been reported to be a receptor for endotoxin. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for LPS-LBP (lipopolysaccharide binding protein)-complexes.

Poids moléculaire: ~50kDa

ID gène: 929

NCBI Accession: NP_000582

UniProt: P08571

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades